Aeolus Pharmaceuticals has released preliminary results from a study suggesting that AEOL 20415 could treat antibiotic-resistant bacteria, protecting the lungs in cystic fibrosis (CF). The company said its drug reduced infection, improved body weight and reduced the presence of white blood cells (macrophages and lymphocytes) in an animal model of CF. Brian Day, PhD,…
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Canadians with cystic fibrosis (CF) live 10 years longer than Americans with the disease, a study shows. The life span of the average Canadian with CF was 50.9 years, versus 40.6 years for the average American, according to Anne Stephenson of St. Michael’s Hospital, the lead author of the study.
Using a virus may be a reliable way to treat antibiotic-resistant bacterial infections in cystic fibrosis (CF) patients’ lungs, according to a study. The approach is called phage therapy. Phage is a shortened version of bacteriophage, a virus that infects bacteria. The study, “Phage Therapy Is Highly Effective Against Chronic…
The levels of a protein called calprotectin in the stool could not only be a marker of intestinal disease but could also help determine disease severity in cystic fibrosis (CF), according to a study published in the scientific journal Immunobiology.
Canon BioMedical has developed 21 Novallele genotyping assays that can detect changes within the cystic fibrosis transmembrane conductance regulator (CFTR) — the defective gene in cystic fibrosis (CF) patients. Different types of genetic mutations in the CFTR gene cause diseases. These range from single nucleotide polymorphisms (SNPs, the most common type of…
Data from the recently completed Phase 2 trial of Resunab (JBT-101) for cystic fibrosis (CF) treatment will be available by March 31, Corbus Pharmaceuticals has announced. The study (NCT02465450) included 85 patients who were treated at CF centers in the United States, Belgium, France, Germany, Italy, Poland and…
The University of Pittsburgh has agreed to conduct a Phase 1 and 2 clinical trial of Aries Pharmaceuticals‘ AIR001 for treating Pseudomonas aeruginosa bacteria infections in patients with cystic fibrosis (CF). Researchers from the university and the University of Pittsburgh Medical Center will work together on the open-label safety and proof-of-concept trial. Aries, a…
Vertex Pharmaceuticals is acquiring CTP-656, a potentiator treatment for the protein that is defective in cystic fibrosis, from Concert Pharmaceuticals. CTP-656, a deuterium-modified version of the therapy ivacaftor, is a next-generation cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, meaning that it enhances the activity of the CFTR protein. CTP-656 has received…
Treatment with hyertonic saline administered before airway clearance is no more effective than when administered during airway clearance in cystic fibrosis, found a study published in BMJ Open Respiratory Research.
PTC Therapeutics’ ataluren has failed to significantly improve respiratory function in nonsense mutation cystic fibrosis (nmCF), a severe form of the disease, according to results of a Phase 3 clinical trial. “We are disappointed with the outcome of this trial as there are no treatments that target the underlying cause…
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