Researchers from Queen’s University Belfast in Northern Ireland have not only discovered why antibiotics are becoming less effective at treating infections in cystic fibrosis (CF) patients — but have also found a potential solution: fat-soluble vitamins. Lung infections, mostly those caused by bacteria, are a serious problem for people with CF and are…
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Stem cell therapy may reduce lung inflammation in cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD), according to preliminary results of a pre-clinical-trial study. The findings, presented at this year’s Lung Science Conference in Estoril, Portugal, could lead to new ways to treat the diseases. The title of…
A wide range of genetic diversity in a bacteria common in the lungs of cystic fibrosis (CF) patients may explain why some develop life-threatening infections while others appear unaffected, according to a study. The research, “Phenotypic diversity and genotypic flexibility of Burkholderia cenocepacia during long-term chronic infection…
Mucus proteins that fail to achieve the correct structure cause airway secretions to become thick and sticky in patients with cystic fibrosis (CF), leading to the well-known symptoms of the disease, according to a study. The reason the proteins fail to assume the shape that’s seen in healthy people is simple,…
Rockefeller University researchers have mapped the three-dimensional structure of the protein involved in cystic fibrosis (CF). The mapping is important because knowing more about the CFTR protein will provide scientists with valuable insight into its activity and may lead to novel therapies for CF. Findings of the study, “Molecular…
Galapagos initiated a Phase 1 trial to evaluate its investigational drug GLPG3067 for cystic fibrosis (CF), triggering a $7.5 million milestone payment from AbbVie, its collaboration partner. Galapagos and AbbVie began a global collaboration in September 2013 to discover, develop and commercialize potentiator and corrector molecules for the…
Sound Pharmaceuticals has received a $1.6 million Cystic Fibrosis Foundation Therapeutics (CFFT) grant to test a therapy it has developed to improve hearing loss in cystic fibrosis (CF) patients being treated with tobramycin. Tobramycin is an antibiotic used to treat flare-ups in CF patients’ lung problems that are known as acute pulmonary exacerbations.
Kalydeco (ivacaftor, VX-770) improves bicarbonate secretion in cystic fibrosis (CF) patients with a certain gene mutation, according to a study. Bicarbonate is essential to digestion and the flow of several secretions in the body, including those of the intestine and pancreas. The report, “Impact of CFTR…
The activity of Zerbaxa (ceftolozane/tazobactam, or C/T) alone or in combination with other antibiotics shows promise against multi-drug resistant (MDR) Pseudomonas aeruginosa infection in pediatric cystic fibrosis (CF) patients, new research shows. The study, “In vitro Activity of Ceftolozane/Tazobactam Alone or with an Aminoglycoside Against Multi-Drug-Resistant Pseudomonas aeruginosa…
Cystic fibrosis (CF) patients have a poorer diversity of gut bacteria than healthy people, and it gets worse as the disease progresses, an Irish study indicates. In addition, patients with severe lung impairment have significantly fewer bacterial species in their gut than those with mild lung problems, researchers found. Because frequent intravenous antibiotic…
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