News

Researchers may have come one step closer to more effective treatments against Pseudomonas aeruginosa growing in layers known as harmful biofilms. A compound found in soil bacteria prevented the bacteria from forming biofilms, which is a serious health threat to patients with cystic fibrosis. The findings, published in the journal…

Under a research contract award granted by the Cystic Fibrosis Foundation Therapeutics (CFFT), Matinas BioPharma and the Colorado State University (CSU) will jointly conduct preclinical studies assessing the efficacy of MAT2501, a potential oral antibiotic, in treating nontuberculous mycobacterium infection (NTM) in a cystic fibrosis (CF) lung model.

Measuring antibodies in the blood and administering lung-function tests, either alone or in combination, significantly increase health-care specialists’ ability to detect the serious bacteria Pseudomonas aeruginosa in children with cystic fibrosis (CF). The study, “Assessment of serology and spirometry and the combination of both to complement microbiological isolation…

Hyperglycemia (high glucose/sugar levels) and infection with Pseudomonas aeruginosa bacteria can acidify the airway surface liquid in patients with cystic fibrosis (CF), especially in those with diabetes as well, contributing to disease pathogenesis, researchers report. Their study, “Hyperglycaemia and Pseudomonas aeruginosa acidify cystic fibrosis airway surface liquid by elevating epithelial monocarboxylate…

Scientists have identified the three-dimensional structure of the protein responsible for cystic fibrosis (CF), a development that will help them understand how mutations of the protein lead to the disease. They also found an area in the protein where many disease-causing mutations are located, and a region within that area…

Researchers at the University of Limerick, in Ireland, have developed a disposable percussion device, called SoloPEP, that works to remove mucus from the airways of people with cystic fibrosis (CF) so as to lessen their likelihood of infections, leading  to fewer doctor’s appointments, less antibiotic use, and shorter hospital stays. “SoloPEP…

The Gregory Fleming James Cystic Fibrosis Research Center (CFRC) at the University of Alabama at Birmingham (UAB) has acquired a MILabs adaptive X-ray CT system to conduct research in animal models of lung diseases, mainly in cystic fibrosis, but also in pulmonary fibrosis, chronic obstructive pulmonary disease (COPD), and sinonasal conditions.

Researchers at the University of Pittsburgh have been awarded with a $1.7 million grant from the National Institutes of Health (NIH) to develop better ways of evaluating, and potentially treating, cystic fibrosis (CF). Specifically, the grant will be used to develop mathematical models of liquid and ion transport in the human…

A Phase 1 clinical trial will evaluate the safety and tolerability of GLPG2737 as a possible treatment for cystic fibrosis (CF), Galapagos NV announced. CF is caused by mutations in the CFTR gene, which encodes a protein channel with the same name. When mutated, this protein can no longer transport chloride…

Several factors may worsen lung infections caused by the bacteria Staphylococcus aureus in cystic fibrosis (CF) patients, from bacterial load to co-infections, according to a new study. The study, “Factors Associated With Worse Lung Function In Cystic Fibrosis Patients With Persistent Staphylococcus aureus,” was published in the journal PLoS One.