Treating patients with cystic fibrosis (CF) or chronic obstructive pulmonary disease (COPD), infected with the fungus Aspergillus fumigatus, with antifungal therapies may contribute to the adaptation and resistance of this microorganism, and exacerbate lung infection, a new study reported. This finding, in a report by medical researchers in the Netherlands, underscores the…
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Vertex Pharmaceuticals reported that the U.S. Food and Drug Administration (FDA) has granted approval for its cystic fibrosis (CF) drug Orkambi to be used to treat children, ages 6 to 11, who have two copies (one inherited from each parent) of the F508del mutation in the CFTR gene. Having two…
Results of a clinical trial evaluating Resunab (JBT-101) in a model of inflammation in healthy subjects indicated that this drug may be a treatment for chronic immune responses linked to tissue inflammation and cystic fibrosis (CF). The results were recently presented at this year’s 6th European Workshop on Lipid Mediators, that…
Pharmaxis announced that Bronchitol (mannitol) has been approved in Russia for the treatment of both pediatric and adult patients with cystic fibrosis (CF), the largest market to date for the medication with this indication. Bronchitol is also approved to treat pediatric and adult CF patients (older than age 6) in Australia, and…
Toxins produced by mold found on nuts and corn can exacerbate cystic fibrosis (CF) and pave the way for airway infections, as they block self-protective mechanisms for the lungs. The study, “Fungal Aflatoxins Reduce Respiratory Mucosal Ciliary Function,” published in the journal Scientific Reports, showed that the toxins…
Proteostasis Therapeutics announced it will present preliminary data from its ongoing Phase 1 clinical trial evaluating ascending doses of PTI-428, an oral treatment for people with cystic fibrosis (CF). The data will be presented at the 30th Annual North American Cystic Fibrosis Conference (NACFC 2016), taking place Oct. 27–29 in Orlando, Florida.
Certain molecules present in the sputum — “coughed-up” material from the trachea and lungs — can help to predict the onset of an inflammation attack in patients with cystic fibrosis (CF), a new study by researchers at the University of California reported. The study, “Metabolomics Of Pulmonary Exacerbations Reveals The Personalized Nature Of…
Penn State researchers developed a fluorescent sensor able to easily and accurately detect salt concentrations in the sweat or other bodily fluids. Based on citric acid molecules, the sensor is highly sensitive and selective for chloride, the main diagnostic marker for cystic fibrosis (CF), and may enable rapid and low-cost…
The Boomer Esiason Foundation (BEF) announced that its cystic fibrosis (CF) ambassador, Jerry Cahill, has joined with Emily Schaller, a CF patient inspired by Cahill to start running and cycling in 2007, in the BEF’s 3rd Annual Bike to Breathe event, running now through Sept. 26. The two are riding 600 miles…
Corbus Pharmaceuticals announced that its CEO will give an update on clinical work and anticipated milestones for Resunab (JBT-101), the company’s synthetic oral drug designed to resolve chronic inflammation and fibrosis, at the upcoming Jefferies Cystic Fibrosis Summit. The treatment is under evaluation in three Phase 2 clinical trials. Last year, Corbus received…
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