Young adults with cystic fibrosis (CF) are particularly vulnerable to depression. As a consequence, these patients may have low rates of adherence to treatments and a severely impaired quality of life, researchers report. The study, “Associations between adherence, depressive symptoms and health-related quality of life in young adults with…
Prenatal testing of people of reproductive age using an expanded carrier screening may increase the detection of hypothetical future fetuses at risk for up to 94 severe or profound conditions including cystic fibrosis, compared to the current recommendations by professional organizations, according to a recent study. Severe conditions are defined as…
Vertex Pharmaceuticals recently gave an update on its Phase 3 development program, which consists of four studies, on the investigational compound VX-661 in combination with Kalydeco (ivacaftor) as a treatment of patients with cystic fibrosis (CF). The company plans to terminate one study, which is investigating VX-661 plus ivacaftor in people with one copy of…
Burkholderia contaminans, a bacteria belonging to the Burkholderia cepacia complex (Bcc) is indeed an opportunistic pathogen in cystic fibrosis according to a study conducted by a team of international researchers.
Proteostasis Therapeutics announced it is now enrolling cystic fibrosis patients and healthy adults in two Phase 1 clinical trials evaluating its lead drug candidate PTI-428. PTI-428 is an oral amplifier of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Amplifiers are CFTR modulators that selectively increase the amount of an…
Arch Biopartners and Catalent Inhalation, a division of Catalent Pharma Solutions, have entered agreements to start manufacturing AB569 for human trials in patients with chronic and antibiotic resistant bacterial lung infections. Representing a large part of the group affected, patients with cystic fibrosis (CF) stand to benefit most. AB569, invented by Daniel Hassett,…
The Japanese Patent Office has granted AmpliPhi Biosciences a patent for the “Beneficial effects of bacteriophage treatments” targeting Pseudomonas aeruginosa infections. A similar patent has already been granted in the United States and a request for one has been filed in Canada. In Australia and in the European…
New four-dimensional computed tomography (4DCT) for lung scans, developed by Professor Andreas Fouras at Monash University, offers the potential to revolutionize treatment for the millions of patients worldwide with lung diseases like cystic fibrosis. The 4DxV X-ray imaging technology, developed and commercialized by Professor Fouras’ technology company 4Dx, provides a state-of-the-art, noninvasive…
A team of scientists from Ulster University, in Northern Ireland, United Kingdom, have joined a nearly $980,000 global research study seeking alternative treatment options for patients with cystic fibrosis-related diabetes (CFRD). The new three-year Strategic Research Centre (SRC) study is the first of its kind funded by the Cystic Fibrosis Trust…
Cystic fibrosis (CF) is a condition known to be linked to lung problems, but bone health can also be impacted in people with the disease. A new paper from researchers in the United Kingdom focuses on this problem. The report, “Bone health and disease in cystic fibrosis,“…
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