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Substantial health benefits can be gained by cystic fibrosis (CF) patients who exercise more, but to accurately assess the impact of such interventions, physicians need to test for exercise capacity and habitual physical activity. In the session, “Let’s Get Moving: Best Practices in Exercise & Physical Activity…

The importance of investigating the role of the airway microbiome in lung damage associated with cystic fibrosis (CF) was the focus of two talks at the recent 30th Annual North American Cystic Fibrosis Conference (NACFC) in Orlando, Florida. Both talks were based on the topic, “Microbiome Studies Can be Helpful in Understanding CF Infections.” CF and CF manifestations, particularly…

Developing a vaccine against infections in patients with cystic fibrosis (CF) is challenging, and to succeed researchers need a deeper understanding of the natural history of CF lung infections. Joanna Goldberg, PhD, with Emory University School of Medicine, detailed the difficulties specific to such vaccine discovery in her talk, “Vaccines for CF Infections: Episode…

TGV-inhalonix reported  that its therapeutic agent Mul-1867  is continuing to show promise in treating antibiotic-resistant lung infections — namely, mixed bacterial and fungal infections — in patients with cystic fibrosis (CF), and it is planning to bring the treatment into clinical testing in the U.S. within two years. Data…

There is not enough data to assess the effectiveness of birth control options in women with cystic fibrosis (CF), in whom an unplanned pregnancy may carry substantial risks for both the mom and the fetus. A session titled “Interesting Challenges in Women’s Health in Cystic Fibrosis,” discussed these topics in…

In a recent talk, researchers showed the enhanced benefits of two next-generation CFTR correctors in cystic fibrosis (CF) patients with specific mutations. The positive results support the clinical evaluation of both drugs in early-stage clinical trials. The talk, “Discovery and biological profile of next-generation CFTR correctors,” was recently presented at the…

A new database to improve the characterization of cystic fibrosis (CF) patients and more effectively identify variables that may impact patient success following lung transplant, was proposed recently at the 30th Annual North American Cystic Fibrosis Conference (NACFC), Oct. 27-29, in Orlando, by Dr. Elliott Dasenbrook, of the Cleveland Clinic. Dasenbrook proposed the database in…

Fewer than half of the cystic fibrosis (CF) patients eligible for treatment with Orkambi (lumacaftor/ivacaftor) used the medication at the end of its first year on the market, an especially low number when compared to the spread of Kalydeco (ivacaftor) use. The study, “Uptake of Lumacaftor-Ivacaftor Use…

Patients with very advanced cystic fibrosis (CF) lung disease who get a lung transplant have the same chances of survival as CF patients with more stable disease, according to a recent study. The findings suggest that lung transplants are not only appropriate for the sickest patients, but the approach is…

Differences in survival between adults with cystic fibrosis (CF) in Canada and the U.S. likely are explained by a delayed introduction of nutritional support for patients, according to a recent study. However, the findings, presented at the 30th Annual North American Cystic Fibrosis Conference (NACFC), held in Orlando, Florida…