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Adult patients with cystic fibrosis (CF) show improvements in lung function decline when treated with a high dosage of tiotropium bromide taken over a long term (24 months). Patients with cystic fibrosis often succumb to chronic lung disease, the leading cause of death among cystic fibrosis patients. Chronic lung disease is often…

Vertex Pharmaceuticals and Moderna Therapeutics recently entered a three-year research partnership and licensing agreement to discover and develop the messenger ribonucleic acid, trademarked as (mRNA) Therapeutics, for the treatment of cystic fibrosis (CF). The alliance between the two companies will center on usimg mRNA drugs to treat the CF  at its core, by…

Nivalis Therapeutics Inc. recently announced that they finished enrolling participants for a Phase 2 clinical trial testing their lead compound N91115 for the treatment of cystic fibrosis (CF).

A recently published study proposes that viruses capable of infecting bacteria, called bacteriophages, may be responsible for accelerating the evolution and increasing the impact of Pseudomonas aeruginosa, a bacterial species that causes chronic lung infections in cystic fibrosis (CF) patients.   ‘Temperate phages both mediate and drive…

A recent study confirmed that different structure and composition of airway microbiota (symbiotic helpful and harmful microrganisms) exist in cystic fibrosis (CF) patients with stable or declining lung function; and shed new light on the fact that microbiota in stable lungs provides higher resilience to bacteria than lungs in severe function decline.

Because some cystic Fibrosis (CF) clinics often fail to follow published guidelines for the screening and care of diabetes in CF patients, but self-implemented ways can produce better patient outcomes, a recent study suggests that optimal care can differ from recommendations. CF-related diabetes is an increasingly common complication in CF patients, resulting in substantial…

Researchers are working on a way to deliver high doses of a common anti-inflammatory — ibuprofen — directly into the lungs of cystic fibrosis (CF) patients as a possible therapy. More than 20 years ago, scientists found that ibuprofen was able to slow lung function decline in CF patients when given at high…

Goiter and hypothyroidism — conditions linked to thyroid gland problems — are no longer major concerns for patients with cystic fibrosis (CF), according to recent research showing that only a fraction of patients now have severe thyroid dysfunction, possibly mirroring lesser use of iodine-based drugs. The study, “Thyroid Function in…

Alaxia SAS announced that it has received $1.7 million from the Cystic Fibrosis Foundation Therapeutics (CFFT), the non-profit drug discovery and development arm of the Cystic Fibrosis Foundation (CFF), to support and advance a first clinical study of its inhaled antimicrobial drug candidate, ALX-009, as a therapy for people with cystic fibrosis…

Pulmatrix recently released an educational, animated video to raise awareness of problematic complex lung diseases and to describe encouraging new dry treatment options for patients with lung conditions including cystic fibrosis (CF). The video can be watched here: [ir.pulmatrix.com] It begins “Everyday you take over 20,000 breaths. Imagine if everyone of…