In a recent agreement with the Indiana University Research and Technology Corp. (IURTC), La Jolla Pharmaceutical Co. acquired intellectual property rights covering next-generation derivatives of gentamicin, an antibiotic used in the treatment of several types of bacterial infections, namely heart, urinary tract, and pregnancy-related infections. Gentamicin treatment is effective…
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What We Hope For I have found myself chasing a deferred hope waiting for my health to change, while watching it steadily decline. The release of Kayldeco by Vertex Pharmaceuticals Inc. in 2012 was a demonstration that the next generation of medications in cystic fibrosis therapy could begin to…
Despite every effort to design a drug effective in helping cystic fibrosis patients with defective CFTR proteins, sometimes drugs are thwarted by mechanisms orchestrated by other proteins within cells. A group of researchers from the Department of Human Genetics at National Health Institute Doutor Ricardo Jorge in Portugal recently published…
Researchers at the University of Missouri–Columbia have discovered two key amino acids in the protein that is associated with cystic fibrosis (CF) — cystic fibrosis transmembrane conductance regulator (CFTR) protein. The study is entitled “Localizing a gate in CFTR” and was published in the journal…
Researchers from The University of Texas at Austin recently revealed that the pathogenic bacteria Pseudomonas aeruginosa has the capacity to inhibit its own growth and the growth of antibiotic-resistant mutants. The study entitled “The spatial profiles and metabolic capabilities of microbial…
Caleigh Haber is an artist, blogger and the focus of this month’s Happiness Stories video series. To celebrate Cystic Fibrosis Awareness Month, the series is sharing the story of Caleigh, who despite living with cystic fibrosis (CF), tries to always see…
Two Phase III clinical trials from Northwestern University’s Feinberg School of Medicine and Stanley Manne Children’s Research Institute at Ann Robert H. Lurie Children’s Hospital of Chicago tested a combination treatment plan in patients with cystic fibrosis. The results show that lumacaftor/ivacaftor, to be marketed under the…
14 year-old Chilean teenager Valentina Maureira became internationally known when she posted a video on YouTube asking the government’s permission to end her life. Valentina suffered from cystic fibrosis, and a month after her plea to the Chilean President Michelle Bachelet was refused, she died from complications associated…
The cystic fibrosis (CF) community will get a firsthand look at the anticipated findings of the Wave 1 multi-dose trial conducted by the Gene Therapy Consortium (GTC), which includes the University of Oxford’s Gene Medicine Group, the University of Edinburgh’s Centre for Molecular Medicine and Roslin Institute, and Imperial College…
An international research team led by researchers at the Sapienza University of Rome in Italy reported that the assessment of daily physical activity in adult patients with cystic fibrosis (CF) could be used as a valuable tool to determine their aerobic fitness and exercise performance. The study was published in…
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