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Freezing and thawing breast milk negatively affected how nutrients are digested under lab conditions mimicking the gastrointestinal environment of an infant with cystic fibrosis (CF), scientists report. The addition of pancreatic enzyme replacement therapy (PERT) at sufficient doses was able to restore more normal fat breakdown under CF…

Oral red ginseng extract eased the signs of cystic fibrosis (CF) in the lungs of rats, a study reports. The extract’s effect was thought to enhance the activity of TMEM16A, a chloride transport protein similar to CFTR, which is defective in CF. The treatment improved chloride flow and reduced…

Men with cystic fibrosis (CF) commonly have low testosterone levels, though this is likely underrecognized due to a lack of testing, a new study highlights. The findings underscore the importance of checking testosterone levels in men with CF so that interventions can be discussed if warranted, researchers said in…

Dietary factors were associated with measures of glucose tolerance — how well the body processes sugar in the bloodstream — among cystic fibrosis (CF) patients in a recent report. Left uncontrolled, impaired glucose tolerance is associated with the development of CF-related diabetes, or CFRD, where blood sugar levels…

Telemedicine programs for managing cystic fibrosis (CF) were at least as effective as standard in-clinic care, according to a review study. Adhering to treatment regimens and patient satisfaction with telemedicine improved significantly across most studies examined, and most participants favored continuing with telemedicine. The review study, “…

Electronic home monitoring using a spirometry device may help improve lung function in children with cystic fibrosis (CF), according to a recent study. Specifically, a standard measure of lung function called forced expiratory volume in one second (FEV1) was found significantly improved in children who used the device, compared…

Almost two years of treatment with Kaftrio (elexacaftor, tezacaftor, and ivacaftor) did not affect liver stiffness — an indicator of liver fibrosis — in adults with cystic fibrosis (CF), according to a recent study in the U.K. However, patients with elevated markers of liver stiffness before starting on…

The lungs of people with cystic fibrosis (CF) harbor stem cells with a distinctive proinflammatory genetic signature, a new study shows. Data indicate that the proinflammatory genetic profile of these stem cells is not affected by treatment with CFTR modulators, a class of medications that can boost the…

CFTR modulator therapy was associated with increases in fecal levels of the pancreatic elastase-1 enzyme (FE-1), reflecting improved pancreatic function, among young cystic fibrosis (CF) patients in a recent study. A small subset of patients achieved FE-1 levels high enough that they were no longer considered to have…

The Cystic Fibrosis (CF) Foundation is giving up to $9 million in additional support to advance clinical testing of ARCT-032, a messenger RNA therapy with the potential to benefit anyone with CF, regardless of their disease-causing mutation. Arcturus Therapeutics, the inhalation therapy’s developer, is using the funding…