Adults with cystic fibrosis (CF) and their healthcare providers generally agree that those living with stable disease while on CFTR modulator therapy could wait longer between routine clinic visits, according to surveys. Doctors of adult CF patients were more comfortable with lower lung function thresholds and fewer required visits…
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CFTR modulators, a class of medications used to treat cystic fibrosis (CF), were associated with reductions in the airway burden of Pseudomonas aeruginosa and in the number of bacterial clusters over time, but large aggregates persisted, a study suggests. While CFTR modulator use was linked to a lower overall…
Children and adolescents with cystic fibrosis (CF) showed increased oxidative stress, which can cause cellular damage, higher inflammation, and reduced activity in the nervous system that helps regulate heart rate, even when their lung disease was mild, a study reports. The study also found that, in the study population…
A new model based on body composition and hand grip strength may help clinicians identify children with cystic fibrosis (CF) at risk of rapid weight gain or weight loss after starting Trikafta (elexacaftor/tezacaftor/ivacaftor), a new study suggests. In 27 children treated with Trikafta, researchers found that weight responses…
Parent caregivers of people with cystic fibrosis (CF) want a tailored, internet-delivered resource offering mental health support, disease education, and connection with other CF families, a study in Canada showed. Researchers said the information gained from the interview-based study will be used “to develop an accessible, tailored, Internet-delivered resource…
People with cystic fibrosis (CF) in Canada are a step closer to gaining public access to Alyftrek, a once-daily triple-combination therapy approved for patients ages 6 and older with at least one mutation that’s responsive to the therapy. Vertex Pharmaceuticals, which markets Alyftrek, has signed a letter…
Arcturus Therapeutics is partnering with Thermo Fisher Scientific to support the development of ARCT-032, Arcturus’ experimental inhaled therapy for cystic fibrosis (CF). Under the agreement, Thermo Fisher will provide Arcturus with manufacturing and clinical trial support for a planned Phase 3 study testing ARCT-032. And if the…
Trikafta (elexacaftor, tezacaftor, and ivacaftor) may improve blood sugar control in people with cystic fibrosis (CF), including those with CF-related diabetes, or CFRD, a study showed. After about one year of treatment, patients with CFRD showed clinically meaningful reductions in glycated hemoglobin (HbA1c), a measure of average blood sugar…
Women with cystic fibrosis (CF) may experience worsening respiratory and digestive symptoms around their menstrual periods, even when taking CFTR modulators, according to a new U.S. study. Researchers found that symptoms such as coughing up mucus, bloating, stomach pain, and painful bowel movements tended to be worse during menstruation than…
Sunflower seeds may offer significant digestive, nutritional, and gut bacteria benefits for children with cystic fibrosis (CF), according to a new laboratory study. Researchers used in vitro (lab-based) techniques to simulate the digestion of various nuts and seeds and to estimate their effects on gut microbiota, or communities of…
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