News

A Phase 2a clinical trial testing RCT2100, Recode Therapeutics’ investigational inhaled mRNA therapy for cystic fibrosis (CF), is fully enrolled, with results expected by the end of the year, the company announced. The clinical updates were part of a broader company announcement focused on Recode’s CF programs, which also…

For children with cystic fibrosis (CF) who are taking Trikafta (elexacaftor/tezacaftor/ivacaftor), weight gain was associated with decreasing levels of inflammation in the body, a Swiss study reports. The association was seen in both short- and long-term analyses after treatment began. Changes in inflammation and body mass index (BMI),…

Cutting-edge DNA sequencing technologies for microbial surveillance have the potential to revolutionize how lung infections in people with cystic fibrosis (CF) are diagnosed and managed, according to a new review study. However, researchers noted that there are still challenges that need to be overcome before these technologies can be…

Use of Trikafta, an approved oral medication for cystic fibrosis (CF), can reduce airway inflammation — known to exacerbate symptoms — in people with the genetic disease, a new study demonstrates. However, after a year of treatment, CF patients on Trikafta still show differences in airway inflammation compared with…

The Cystic Fibrosis Foundation is funding a new research project that aims to develop a cell-based strategy for rebuilding damaged airway tissue in people with cystic fibrosis (CF). Do-Yeon Cho, MD, a professor in the Department of Otolaryngology–Head and Neck Surgery at the University…

Using two new sensitive lung tests, researchers in Europe were able to identify subtle changes indicating worsening cystic fibrosis (CF) in people with the genetic disease — even when standard breathing assessments showed stable lung function. These tests — an oxygen-enhanced MRI and the multiple breath washout with Short…

One year of treatment with Kaftrio lowered levels of certain immune cells implicated in inflammation, led to fewer pulmonary exacerbations, and reduced detection of Pseudomonas aeruginosa in people with cystic fibrosis (CF), a real-world study found. The reductions in neutrophils and monocytes — types of white blood…

Dental problems, particularly untreated tooth cavities, are associated with poor lung health and reduced respiratory-related quality of life in young people with cystic fibrosis (CF), a study suggests. Adolescents and young adults with CF who had more extensive untreated cavities had worse lung function and reported a larger impact…

Women with cystic fibrosis (CF) who continue on CFTR modulator therapy during pregnancy show stable health and no increase in birth complications, according to a new review. At the same time, published case reports and small studies have found that intentionally treating a baby with CF before birth…

In an interview study, adults with cystic fibrosis who also developed diabetes reported that using a new type of insulin delivery system led to wide-ranging improvements in their daily lives, including easier blood sugar management and needed weight gain. For many, the use of the hybrid closed-loop system —…