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One year of treatment with Trikafta modestly eased some digestive symptoms and led to fewer reports of constipation in children with cystic fibrosis (CF), although those were already low before the triple-combination therapy, a new study reports. It also increased the proportion of patients with normal levels of fecal…

Lower insulin doses and less blood sugar variability were observed one year after adults with cystic fibrosis-related diabetes (CFRD) started Kaftrio. That’s according to results from the DIATRIM study (NCT06331000), a real-world, multicenter observational study conducted at 13 centers in France. Researchers retrospectively analyzed data from adults with…

Cystic fibrosis (CF) likely affects as many babies in parts of Asia, Africa, and South America as in Europe and the U.S., and better genetic testing and broader access to effective treatments are urgently needed worldwide, a study suggests. The study, “Analysis of the Genome Aggregation Database (gnomAD)…

Scientists have developed a more precise version of a gene-editing tool, showing that it can correct mutations that cause cystic fibrosis (CF) in cell models and also introduce CF-causing mutations into cells for research. “We were able to introduce specific cystic-fibrosis mutations into human epithelial cells relevant to the…

Long-term exposure to fine particulate matter, a type of air pollution, accelerates the decline in lung function among people with cystic fibrosis (CF) living certain areas of London, according to a new study. The research showed that CF patients exposed to higher levels of fine particulate matter experienced significantly…

Researchers at UCLA have developed a nonviral gene-editing strategy that could help pave the way for one-time treatments for people with cystic fibrosis (CF). The experimental therapy uses lipid nanoparticles — tiny fatty molecules — to insert a full, healthy copy of the CFTR gene into human airway cells,…

Routine blood tests can accurately predict the development of an allergic response to the fungus Aspergillus in children with cystic fibrosis (CF), a study suggests. A higher risk of the lung allergic response, called allergic bronchopulmonary aspergillosis (ABPA), was found among those with elevated biomarker levels for up…

Children with cystic fibrosis (CF) have lower gut levels of certain short-chain fatty acids (SCFAs), metabolites made by beneficial gut bacteria that help regulate inflammation, a study reports. The researchers also found that children with CF had lower dietary fiber intake, reduced gut microbial diversity, fewer key SCFA-producing bacteria,…

Handgrip strength was associated with breathing muscle strength in adults with cystic fibrosis (CF), according to a new study, suggesting the simple test may help complement standard lung function tests in clinical care. The research also found that lung function and breathing muscle strength were related to a combination…

Short-term increases in air pollution can trigger pulmonary exacerbations — disease flares marked by a sudden worsening in lung function — in people with cystic fibrosis (CF), a new study shows. Notably, the study found that increased pollution doesn’t trigger exacerbations right away — the data suggest that…