News

Trikafta (elexacaftor, tezacaftor, and ivacaftor) may improve blood sugar control in people with cystic fibrosis (CF), including those with CF-related diabetes, or CFRD, a study showed. After about one year of treatment, patients with CFRD showed clinically meaningful reductions in glycated hemoglobin (HbA1c), a measure of average blood sugar…

Women with cystic fibrosis (CF) may experience worsening respiratory and digestive symptoms around their menstrual periods, even when taking CFTR modulators, according to a new U.S. study. Researchers found that symptoms such as coughing up mucus, bloating, stomach pain, and painful bowel movements tended to be worse during menstruation than…

Sunflower seeds may offer significant digestive, nutritional, and gut bacteria benefits for children with cystic fibrosis (CF), according to a new laboratory study. Researchers used in vitro (lab-based) techniques to simulate the digestion of various nuts and seeds and to estimate their effects on gut microbiota, or communities of…

People with cystic fibrosis (CF) continued to receive less recommended routine CF care through 2023 than they did before the COVID-19 pandemic, with adults showing the largest declines, a U.S. study found. Although care gradually rebounded after the pandemic, in-person clinic visits, lung function tests, and bacterial cultures remained…

KIT2014, an experimental inhaled therapy by Kither Biotech, was safe and well tolerated in healthy volunteers, according to Phase 1 trial results, potentially supporting further development of the medication for cystic fibrosis (CF) and other lung conditions. “We are pleased to report the successful completion of this first-in-human…

People with cystic fibrosis (CF) may have altered responses to high temperatures compared with healthy individuals, a study in Cyprus suggests. Using wearable sensors during hot and cooler seasons, researchers found that while both groups were exposed to similar temperatures, people with CF showed smaller changes in blood pressure,…

CF-related diabetes (CFRD) patients are able to adhere to their treatment routines, and the condition doesn’t hurt their mental health or cognitive functioning despite posing a greater treatment burden than cystic fibrosis (CF) alone, a U.S. study found. In an analysis of almost 400 participants, people with CFRD…

Children with cystic fibrosis (CF) who were using CFTR modulators had lower anxiety scores than those not using the treatments, while their parents had lower anxiety and depression scores, according to a small, single-center study in Turkey. The findings suggest these treatments may be linked to mental health benefits…

For adults with cystic fibrosis (CF), long-term treatment with Trikafta (elexacaftor/tezacaftor/ivacaftor) may significantly improve the composition of bacteria living in the lungs, a study found. The study showed that with longer periods of Trikafta treatment, the community of lung bacteria (respiratory microbiota) became more diverse. Disease-causing (pathogenic) bacteria…

Kaftrio (elexacaftor/tezacaftor/ivacaftor) use was not associated with additional improvements in physical activity among children and adolescents with cystic fibrosis (CF) in a small observational study. Even so, those who started Kaftrio during the study or were already receiving it showed improvements in some health-related quality-of-life domains, including treatment…