A new model based on body composition and hand grip strength may help clinicians identify children with cystic fibrosis (CF) at risk of rapid weight gain or weight loss after starting Trikafta (elexacaftor/tezacaftor/ivacaftor), a new study suggests. In 27 children treated with Trikafta, researchers found that weight responses…
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Parent caregivers of people with cystic fibrosis (CF) want a tailored, internet-delivered resource offering mental health support, disease education, and connection with other CF families, a study in Canada showed. Researchers said the information gained from the interview-based study will be used “to develop an accessible, tailored, Internet-delivered resource…
People with cystic fibrosis (CF) in Canada are a step closer to gaining public access to Alyftrek, a once-daily triple-combination therapy approved for patients ages 6 and older with at least one mutation that’s responsive to the therapy. Vertex Pharmaceuticals, which markets Alyftrek, has signed a letter…
Arcturus Therapeutics is partnering with Thermo Fisher Scientific to support the development of ARCT-032, Arcturus’ experimental inhaled therapy for cystic fibrosis (CF). Under the agreement, Thermo Fisher will provide Arcturus with manufacturing and clinical trial support for a planned Phase 3 study testing ARCT-032. And if the…
Trikafta (elexacaftor, tezacaftor, and ivacaftor) may improve blood sugar control in people with cystic fibrosis (CF), including those with CF-related diabetes, or CFRD, a study showed. After about one year of treatment, patients with CFRD showed clinically meaningful reductions in glycated hemoglobin (HbA1c), a measure of average blood sugar…
Women with cystic fibrosis (CF) may experience worsening respiratory and digestive symptoms around their menstrual periods, even when taking CFTR modulators, according to a new U.S. study. Researchers found that symptoms such as coughing up mucus, bloating, stomach pain, and painful bowel movements tended to be worse during menstruation than…
Sunflower seeds may offer significant digestive, nutritional, and gut bacteria benefits for children with cystic fibrosis (CF), according to a new laboratory study. Researchers used in vitro (lab-based) techniques to simulate the digestion of various nuts and seeds and to estimate their effects on gut microbiota, or communities of…
People with cystic fibrosis (CF) continued to receive less recommended routine CF care through 2023 than they did before the COVID-19 pandemic, with adults showing the largest declines, a U.S. study found. Although care gradually rebounded after the pandemic, in-person clinic visits, lung function tests, and bacterial cultures remained…
KIT2014, an experimental inhaled therapy by Kither Biotech, was safe and well tolerated in healthy volunteers, according to Phase 1 trial results, potentially supporting further development of the medication for cystic fibrosis (CF) and other lung conditions. “We are pleased to report the successful completion of this first-in-human…
People with cystic fibrosis (CF) may have altered responses to high temperatures compared with healthy individuals, a study in Cyprus suggests. Using wearable sensors during hot and cooler seasons, researchers found that while both groups were exposed to similar temperatures, people with CF showed smaller changes in blood pressure,…
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