Lindsey Shapiro, PhD, science writer —

Being treated with Kaftrio or Symveki led to a reduced need for insulin in people with cystic fibrosis-related diabetes (CFRD), a small study found. The treatment wasn’t associated with alterations in blood sugar and associated factors in CF patients without diabetes. The findings add to a growing…

The European Commission approved expanding the use of Orkambi (lumacaftor/ivacaftor) to include children as young as 1 year old with cystic fibrosis (CF) and two copies of the F508del mutation in the CFTR gene. Vertex Pharmaceuticals’ therapy was first approved in the European Union…

The personality traits of people with  cystic fibrosis (CF) might influence their health-related quality of life (HRQoL), according to a recent study. Scientists found that patients could be clustered into two distinct personality groups and that self-reported quality of life differed significantly between them. The findings, published in “…

Men with cystic fibrosis (CF) saw greater reductions in lung symptom exacerbations after starting treatment with Trikafta (elexacaftor/tezacaftor/ivacaftor) than their female counterparts, according to a recent study. Changes in nutritional status, lung infections, and lung function were similar between the sexes. The findings overall suggest that high-efficacy therapies…

A young man with cystic fibrosis (CF) has become the first patient in the U.S. to undergo MRI lung imaging combined with Xenoview, a novel technology by Polarean Imaging for visualizing lung ventilation. The scan, done in a 19-year-old CF patient, took place at the Cincinnati Children’s Hospital…

Reducing the use of supportive therapies after starting Trikafta (elexacaftor/tezacaftor/ivacaftor) didn’t negatively impact health outcomes among cystic fibrosis (CF) patients, according to a recent study. Guided by a de-escalation algorithm for safely stopping supportive therapies, patients were able to cut back on such treatments by 50% on average,…

Cystic fibrosis (CF) patients who had fasting blood sugar (glucose) levels that rose more quickly throughout adolescence were more than three times as likely to have abnormal glucose tolerance (AGT) in early adulthood than their peers whose levels rose more slowly, a study found. AGT refers to elevated or…

Among women with cystic fibrosis (CF) who experienced a pregnancy, those that were unplanned were associated with an increased frequency of pulmonary exacerbations after giving birth, according to a recent study. Regardless of whether the pregnancy was planned or unplanned, women experienced declines in lung function after delivery compared…

Chemical signaling within the protective clusters formed by Pseudomonas aeruginosa — a common infection-causing bacteria in cystic fibrosis (CF) — is dependent on factors such as surface type, the presence of antibiotics, and the bacterial strain, a study found. Such infections in CF are often resistant to standard…

Nearly 39,000 people were estimated to be living with cystic fibrosis (CF) in the U.S. in 2020, up from the roughly 34,000 estimate made in 2012, a study led by the Cystic Fibrosis Foundation reported. A majority — about 77% — of these people also took part in…