Lindsey Shapiro, PhD, science writer —

Cystic Fibrosis News Today brought you daily coverage of the latest scientific discoveries, treatment advances, and clinical trials related to cystic fibrosis (CF) this past year. We look forward to continuing to offer you the most up-to-date information in 2023. Here are the 10 most-read CF news articles of 2022,…

For a small group of people with cystic fibrosis (CF), one year of treatment with Orkambi (ivacaftor/lumacaftor) improved bone health and stabilized pancreatic function, nutritional status, reproductive hormone levels, and lung function. These findings from a recent study in Israel demonstrate the use of Orkambi, which targets the…

A recent overall decline in lung transplant rates for adults and children with cystic fibrosis (CF) in the U.S. has had less impact on nonwhite patients, according to a recent analysis. While transplant rates have decreased in the past couple years for all people with CF, the declines were…

Adding a school specialist to cystic fibrosis (CF) care teams could help identify educational risk factors — and provide interventions — to promote school success for children with CF, according to a new study. That study, by specialists at a CF center in Ohio, found that more than half…

High blood-sugar levels at night are associated with poorer lung function in adults, but not in children, with cystic fibrosis (CF), a study has found. During a week of continuous glucose monitoring, blood-sugar abnormalities were observed in almost all CF adults and children evaluated, even when other tests taken over the…

Children with cystic fibrosis (CF) being treated with Orkambi (ivacaftor/lumacaftor) have distinct clinical response profiles after six months of treatment in a real-world setting, a French-Italian study found. While changes in lung function were the largest driver of treatment responses in older children ages 12–18, body mass index…

Children who carry certain mutations associated with cystic fibrosis (CF), but do not have the disease — called CF carriers — may be more likely to develop asthma than children who don’t carry a mutation, a California study found. In particular, inheriting one copy of the most common CF-causing…

Researchers have identified a set of genes that could represent therapeutic targets to prevent severe complications from COVID-19 infection in people with cystic fibrosis (CF). Three of these genes were at higher levels in patients with either COVID-19, CF, or chronic kidney disease (CKD), and a larger network of…

The advent of newborn screening (NBS) programs in the U.S. a decade ago is linked to better outcomes today in children with cystic fibrosis (CF), a new study reports. Results show that children born after CF newborn screening became available in their states have improved nutritional outcomes, better…

Measures of frailty, based on an established index of physical activity, fatigue, weight loss, and the like for older adults, helps in predicting likely outcomes among cystic fibrosis (CF) patients listed for a lung transplant. A greater degree of frailty linked significantly with worsening waitlist status, graft failure, and mortality,…