Margarida Maia, PhD,  science writer—

Some people with cystic fibrosis (CF) have levels of sweat chloride above the cut-off for a diagnosis of the disease despite being on CFTR modulators, suggesting there is room for improving treatment, a study found. The study, “Heterogeneity of CFTR modulator-induced sweat chloride concentrations in people with…

BiomX and Adaptive Phage Therapeutics (APT) are entering into a merger agreement with a goal of pooling resources to advance phage therapies such as BX004 — an experimental cystic fibrosis (CF) treatment that aims to clear up lung infections caused by Pseudomonas aeruginosa bacteria. At the same time as…

The Cystic Fibrosis Foundation (CFF) is encouraging individuals and nonprofits to apply by April 5 for one of its 2024 CFF Impact Grants, which provide as much as $10,000 in funding to programs that help people with cystic fibrosis (CF) or their families live their lives to the…

In children with cystic fibrosis (CF) treated with Orkambi (ivacaftor/lumacaftor), the levels of the medication reached in the blood depend on how much the children weigh and how well their liver is working, a new study discovered. These findings offer insights into how to best adjust doses of the approved…

Certain markers of inflammation found deep in the lungs of children with cystic fibrosis (CF) can help predict how bronchiectasis will worsen over time, offering insights for better treatment and care, a study suggests. Among other markers, higher levels of interleukin-8 (IL-8), a signaling…

Between 2011 and 2021, improving lung function and better survival rates were consistently seen among people with cystic fibrosis (CF) in Europe, particularly in wealthier countries and with the introduction of new treatments, according to a study that tracked more than 45,000 CF patients across the continent over the…

The antibiotic arenicin may be effective at killing resistant Mycobacterium abscessus, a type of bacteria that can cause serious infections in people with cystic fibrosis (CF), according to a study in cells. Given alone or in combination with conventional antibiotics,…

Staying physically active, especially engaging in more vigorous exercise regularly, is important for lung health and life quality in adolescents and adults with cystic fibrosis (CF), a study reports. Better lung function and exercise capacity were key factors in a patient’s overall quality of life, the researchers found, adding…

No significant link was seen between an increase in body mass index (BMI), a measure of body fat based on weight and height, and higher blood fats and vitamin levels in people with cystic fibrosis (CF) being treated with Trikafta (elexacaftor/tezacaftor/ivacaftor), a study in adult and pediatric patients…

Discontinuing dornase alfa while on Trikafta (elexacaftor/tezacaftor/ivacaftor) could cut down on prescription costs by more than $1 billion each year in the U.S., according to estimates based on data from a randomized controlled trial. The savings would not compromise health, at least not for the short term, as people…