Margarida Maia, PhD,  science writer—

BX004, BiomX’s experimental phage cocktail — a treatment that uses certain viruses to kill disease-causing microorganisms — was seen to reduce the number of Pseudomonas aeruginosa bacteria present in the lungs of people with cystic fibrosis (CF) in the first part of a small trial. The nebulized…

Kaftrio, a combination of elexacaftor, tezacaftor, and ivacaftor marketed as Trikafta in the U.S., may relieve much of the discomfort that’s sometimes experienced by people with cystic fibrosis (CF) in the nose and the air-filled cavities around it, called sinuses, a German study found. The study, “Effects…

Nearly two-thirds of the people with cystic fibrosis (CF) in the U.S. are under financial hardship, and many face unmet medical needs, meaning their treatment is not being addressed adequately. Researchers with George Washington University and the Cystic Fibrosis Foundation, who conducted this analysis into the cost of…

Taking Trikafta (elexacaftor/tezacaftor/ivacaftor) may lead to only a mild rise in liver enzymes in people with cystic fibrosis (CF)-related liver disease, a study found. This is likely not a clinically significant change, “and should not be a barrier to prescription,” the researchers wrote in the study, “Longitudinal effects…

Nearly 8% of people with cystic fibrosis (CF) may be infected with nontuberculous mycobacteria (NTM), a type of bacteria in the environment, a meta-analysis study has found. Researchers observed that the number of cases has surged across the world over the last few years. The bacteria can cause infection…

Trikafta (elexacaftor/tezacaftor/ivacaftor) was seen to keep lung function from getting worse in people with cystic fibrosis (CF) for up to two years, a study found. These findings counter previous studies wherein the active ingredients in Trikafta, alone or in combinations of two, were seen to slow, but not…

Sionna Therapeutics is forging ahead in the new year with its preclinical and clinical programs aimed at developing small molecules — such as SION-638 — as possible treatments for cystic fibrosis (CF). An ongoing Phase 1 trial, now enrolling participants, is testing SION-638 in healthy volunteers. Dosing…

Pseudomonas aeruginosa bacteria can become resistant to the antibiotic tobramycin by clumping into more and larger aggregates and making more of a protective sugar molecule called Psl, a study reported. It used samples of sputum from a small group of children with cystic fibrosis (CF) who received inhaled…

Women with cystic fibrosis (CF) who had a lung transplant are at higher risk of testing positive for the human papillomavirus (HPV), a virus that can cause many cancers, a French study found. Researchers also observed that it was more common for these women than for the general population…

The rate of new cases, or incidence of cystic fibrosis (CF) is gradually and annually decreasing in the U.S. and Canada alike — and has been for nearly a quarter of century — a new study found. From 1995 to 2019, CF incidence has dropped at a rate of…