A new biomaterial made up of nanoparticles showed a potential to improve — by up to 100,000 times — the efficiency of tobramycin, an antibiotic used to treat cystic fibrosis (CF) patients with Pseudomonas aeruginosa infections. Tobramycin, carried within a nanostructured material, completely eradicated P. aeruginosa infection in a…
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Vitamin D intoxication may occur in people with cystic fibrosis (CF) due to accidental errors made by pharmacists in preparing prescriptions, a study has found. Indeed, some 13 patients in the study were taking a dose of vitamin D that was nearly 70 times higher than the prescribed one,…
Combining AzurRx BioPharma‘s investigational therapy MS1819 with standard pancreatic enzyme replacement therapy (PERT) can improve fat absorption in cystic fibrosis (CF) patients with severe exocrine pancreatic insufficiency (EPI), interim data from a Phase 2 clinical trial indicate. “The overarching goal of our MS1819 program is to provide a safe and…
A review of 57 real-world studies found that people with cystic fibrosis (CF) who take Kalydeco (ivacaftor) experience improvements in lung function, nutrition, and quality of life (QoL). Reduced healthcare system use, lower Pseudomonas…
Long-term use of Orkambi (lumacaftor/ivacaftor), an approved cystic fibrosis (CF) treatment, is safe and effective for children between ages 2 and 5 with two copies of the disease-causing F508del mutation in the CFTR gene, a study reported. It draws on results from a Phase 3 open-label extension trial…
When it comes to raising funds for cystic fibrosis (CF), the Cystic Fibrosis Foundation is committed to relentlessly pursuing research initiatives until “CF stands for cure found.” Last year, the foundation put a total of $218.1 million toward research and spent $80 million on its…
Cystic fibrosis (CF) is linked with changes in the types of cells — including stem cells — that compose the tissue lining the airways, a study reported. Specifically, CF patients show an exhaustion in certain basal cells, progenitor-like cells with the capacity to repair and regenerate damaged lung tissue.
Long before COVID-19 changed the world, organ transplant recipients were wearing masks to shield themselves from airborne threats. Immunosuppressive medicines, which often are a lifelong after a transplant, require these people to add an extra layer of protection against viruses as common as a cold or as dangerous as COVID. They…
Human mesenchymal stem cells (hMSCs) effectively treated infections caused by non-tuberculous mycobacteria in cell-based tests and a mouse model of cystic fibrosis (CF), a study revealed. Although this strategy may help treat those infections in people with CF and other lung…
People living with cystic fibrosis (CF) are invited to participate in CF Awareness Month by submitting entries for the CF Awareness Film Festival, taking place virtually May 24–31. Supported by the Bonnell Foundation and the I See You Awards, the festival aims to highlight issues faced by…
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