News

Children with cystic fibrosis (CF) who began taking Orkambi (lumacaftor/ivacaftor) between ages 2 and 5 showed improved height, weight, and body fat content compared with matched patients who hadn’t yet received modulator therapies, a real-world study reports. There was also a 50% decline in the number of pulmonary…

Sotagliflozin, an oral medication approved in the U.S. under the brand name Inpefa as a broadly used treatment for heart failure, may ease symptoms of liver disease related to cystic fibrosis (CF), according to a study in rabbits. While it’s still too early to tell if sotagliflozin will…

Some people with cystic fibrosis (CF) have levels of sweat chloride above the cut-off for a diagnosis of the disease despite being on CFTR modulators, suggesting there is room for improving treatment, a study found. The study, “Heterogeneity of CFTR modulator-induced sweat chloride concentrations in people with…

BiomX and Adaptive Phage Therapeutics (APT) are entering into a merger agreement with a goal of pooling resources to advance phage therapies such as BX004 — an experimental cystic fibrosis (CF) treatment that aims to clear up lung infections caused by Pseudomonas aeruginosa bacteria. At the same time as…

Sionna Therapeutics has raised $182 million in financing to advance the development of small molecules designed to restore CFTR protein function by binding to a specific part of the protein called the first nucleotide-binding domain, or NBD1. Cystic fibrosis (CF) is caused by mutations in the gene…

A New York State assistance program re-launched last year to provide financial aid to adults with cystic fibrosis (CF) for medical costs has a new administrator. The HealthWell Foundation‘s subsidiary HWF Direct has been tapped to administer the state’s Adult Cystic Fibrosis Assistance Program, known as ACFAP.

Stopping treatment with inhaled supportive therapies hypertonic saline (HS) or Pulmozyme (dornase alfa) didn’t negatively affect airway mucus clearance among cystic fibrosis (CF) patients with mild lung disease who were being also treated with Trikafta (elexacaftor/tezacaftor/ivacaftor), a report suggests. Indeed, the findings from the six-week study…

A lipid nanoparticle designed to deliver genetic therapy to lung cells could be used as a platform to treat lung-related diseases like cystic fibrosis (CF), a mouse study found. Researchers developed a way to identify lipid nanoparticles — fatty molecules that help deliver genetic material to cells — that…

The Cystic Fibrosis Foundation (CFF) is encouraging individuals and nonprofits to apply by April 5 for one of its 2024 CFF Impact Grants, which provide as much as $10,000 in funding to programs that help people with cystic fibrosis (CF) or their families live their lives to the…

A persistently stuffy nose is a big concern for people with cystic fibrosis (CF) who have chronic nose inflammation, but loss of smell isn’t as significant a worry, according to a new study that used the SinoNasal Outcome Test (SNOT-22). “Nasal congestion and post-nasal discharge were top priorities reported…