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Treatment with Kaftrio (elexacaftor/tezacaftor/ivacaftor) helps increase fat stores in adults with cystic fibrosis (CF), especially those who are underweight, a study found. Researchers also found small, though statistically significant, increases in muscle mass in patients who started on Kaftrio. The results showed that Kaftrio mainly affects fat tissues,…

Parents of infants and toddlers with cystic fibrosis (CF) often see their children as weighing less than they actually do, and feel they eat more slowly and enjoy food less than healthy children, according to a small U.S. study. Using questionnaires like the Baby Eating Behavior Questionnaire (BEBQ), a…

About every fourth member of the cystic fibrosis (CF) community feels they’re not provided clear information about cross infection and infection prevention and control, according to a survey conducted in 13 countries. Many survey respondents, mostly girls and women, said they’d wash and disinfect their nebulizers more frequently if…

People with cystic fibrosis (CF) who carry two disease-causing F508del mutations and those who have had no prior treatment with CFTR modulators are up to five times more likely to see greater improvement of sinonasal symptoms after starting highly effective modulator treatment, a study found. An improvement of…

Improvements in mucus clearance with the approved medication Trikafta — evident among patients within a month after starting treatment, according to researchers — may contribute to better lung function in people with cystic fibrosis (CF), per a new U.S. study. Mucus clearance mechanisms are meant to keep the…

After starting Trikafta, people with cystic fibrosis (CF) significantly reduced their use of other CF-related medications, suggesting that many people with CF on Trikafta “may prioritize reducing treatment burden over maximizing lung function,” researchers said. Still, lung function continued to decline after Trikafta initiation, they reported in a real-world…

Researchers have developed a device that could improve gene therapy delivery to the lungs for people with genetic conditions such as cystic fibrosis (CF). In a series of preclinical experiments, the research team showed that its device could deliver a therapeutic payload to cells better than a standard inhaler…

Most parents of newborns diagnosed with cystic fibrosis (CF) or a different disease as part of U.S. newborn screening programs said understanding the test results was difficult and about a third said they lacked support from their child’s healthcare team, according to a national survey.

Younger adults with cystic fibrosis (CF) and a history of frequent pulmonary exacerbations are more likely than other adult patients to have put on weight six months into treatment with Trikafta (ivacaftor/tezacaftor/elexacaftor), a study found. The study, “Predicting weight gain in patients with cystic fibrosis on triple…

Treatment with the antibiotic azithromycin reduces abnormal thickening of the walls of bronchi — air passages leading to the lungs — in young children with cystic fibrosis (CF), and this may translate into smoother blood flow to the lungs, a study suggests. Data come from COMBAT-CF (NCT01270074),…