News

Pharmaxis Recruits 400 Cystic Fibrosis Patients for Phase 3 Study of Bronchitol Therapy

Pharmaxis announced that it has completed recruiting adult patients with cystic fibrosis (CF) for its large and potentially pivotal  Phase 3 clinical trial evaluating Bronchitol (mannitol) as an inhaled treatment.  The company expects to report results in the second quarter of 2017. Based on those results, the company will apply for U.S. Food and Drug…

Interleukin-22 Fails to Protect Against Key CF Pathogen and Promotes Weight Loss in Animal Study

Interleukin-22 is known to protect against respiratory pathogens through its ability to mediate mucosal immunity and tissue regeneration. But new research into its possible use against Pseudomonas aeruginosa, a main cystic fibrosis pathogen, found that IL-22 disappointed — with scientists reporting IL-22 failed to protect a mice model from such infection and even seem to…

Vertex, Moderna Collaborate to Discover, Develop mRNA Therapeutics for CF

Vertex Pharmaceuticals and Moderna Therapeutics recently entered a three-year research partnership and licensing agreement to discover and develop the messenger ribonucleic acid, trademarked as (mRNA) Therapeutics, for the treatment of cystic fibrosis (CF). The alliance between the two companies will center on usimg mRNA drugs to treat the CF  at its core, by…

Chronic Lung Infections in CF Patients Worsened by Viruses, Study Says

A recently published study proposes that viruses capable of infecting bacteria, called bacteriophages, may be responsible for accelerating the evolution and increasing the impact of Pseudomonas aeruginosa, a bacterial species that causes chronic lung infections in cystic fibrosis (CF) patients.   ‘Temperate phages both mediate and drive…

Unmet Published Guidelines for CF-Related Diabetes Can Be ‘Incompletely Successful’, Study Shows

Because some cystic Fibrosis (CF) clinics often fail to follow published guidelines for the screening and care of diabetes in CF patients, but self-implemented ways can produce better patient outcomes, a recent study suggests that optimal care can differ from recommendations. CF-related diabetes is an increasingly common complication in CF patients, resulting in substantial…