A miniaturized wearable device is able to measure chloride levels in sweat, the gold standard tool for diagnosing cystic fibrosis (CF). In infants with CF, tests showed the device’s accuracy matched standard methods without the need for trained personnel in hospital settings. It also measured sweat levels of zinc…
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The U.S. Food and Drug Administration (FDA) has granted fast track designation to SPL84, an experimental inhalation therapy for people with cystic fibrosis (CF) caused by the 3849+10 kb C-to-T mutation in the CFTR gene. The designation is given to accelerate the development and review of therapies meant to address unmet…
Two Massachusetts-based companies, Nanite and Saliogen Therapeutics, are teaming up on a new research project that aims to create a genetic medicine with the potential to treat cystic fibrosis (CF). “Nanite’s relationship with SalioGen is consequential in discovering safe polymeric nanoparticles for a transformative treatment for CF,”…
Certain neutrophils, a type of immune cell that’s released quickly into the bloodstream to help fight off infections, appear to be linked to better lung function in some people with cystic fibrosis (CF), a study finds. The presence or abundance in the blood of certain other immune cells and…
Exposure in utero to the cystic fibrosis (CF) medication Trikafta (elexacaftor/tezacaftor/ivacaftor) didn’t appear to negatively affect organ development in fetal rats whose mothers were given it, but it did change the activity of some genes, a study finds. While the functional impacts of the changes remain to be…
One year of treatment with Kaftrio (elexacaftor/tezacaftor/ivacaftor), branded Trikafta in the U.S., helped people with cystic fibrosis (CF) gain exercise capacity, particularly those who saw changes in weight and lung function, according to a study out of Denmark. While there was a significant increase in the highest amount…
This year’s “Fishing for a Cure,” an annual fundraiser hosted by Constellation Energy Corporation, has raised $70,000 for the Cystic Fibrosis Foundation, a nonprofit that helps to support people living with cystic fibrosis (CF) and to fund research for new treatments. “We are in shock by the incredible…
Evoq Bio said it successfully completed a meeting with the U.S. Food and Drug Administration (FDA), held to discuss the development of its inhaled nanoparticle therapy for treating bacterial lung infections in people with cystic fibrosis (CF) and other lung disorders. According to the company, a subsidiary of…
A lung transplant can be lifesaving for children with cystic fibrosis (CF) admitted for respiratory failure to a pediatric intensive care unit (PICU). Only 35% of these young patients went on to be discharged without a transplant, according to an analysis of children with CF treated at a French…
Newborn screening (NBS) in Switzerland correctly identified 96% of cystic fibrosis (CF) cases over an 11-year period, a study found. False negatives, instances where tests are negative but an infant has CF, occurred in 10 out of 272 diagnosed cases. Still, the program did not achieve a positive predictive…
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