News

CDX-7108, an oral therapy being developed by Codexis for exocrine pancreatic insufficiency (EPI) — which is common in people with cystic fibrosis (CF) — may safely improve fat absorption, according to interim data from an ongoing Phase 1 clinical trial. The trial, sponsored by Nestlé Health Science,…

A single round of airway clearance therapy (ACT) led to immediate improvements in some lung function tests for cystic fibrosis (CF) patients, a study found. However, mucus that plugs up the airways wasn’t cleared by a single treatment. Overall findings from the study highlight “the potential remaining importance of…

BX004, BiomX’s experimental phage cocktail — a treatment that uses certain viruses to kill disease-causing microorganisms — was seen to reduce the number of Pseudomonas aeruginosa bacteria present in the lungs of people with cystic fibrosis (CF) in the first part of a small trial. The nebulized…

Teenagers and young adults with cystic fibrosis (CF) appear less likely to smoke cigarettes — tobacco or electronic — and marijuana than their peers, according to a U.S. study. Still, e-cigarette and marijuana use is not uncommon in this patient group, with 18- to 21-year-olds being most at risk. As…

Kaftrio, a combination of elexacaftor, tezacaftor, and ivacaftor marketed as Trikafta in the U.S., may relieve much of the discomfort that’s sometimes experienced by people with cystic fibrosis (CF) in the nose and the air-filled cavities around it, called sinuses, a German study found. The study, “Effects…

Pulmonary exacerbations in adults with cystic fibrosis (CF) fall into three distinct groups based on inflammatory markers in their bloodstream, a pilot study has discovered. These unique inflammatory profiles corresponded to different times from the onset of symptoms to hospitalization, to the rate of lung function decline before…

Cystic fibrosis (CF) patients with CF-related diabetes (CFRD) had a higher gastrointestinal (GI) symptom burden than patients who didn’t have it, a U.K. study found. CFRD patients had more symptoms related to appetite and gastroesophageal reflux disease (GERD), more commonly known as acid reflux or heartburn, as well…

The nonprofit Emily’s Entourage has awarded $220,000 to a project to develop a nonviral and inhalable gene therapy for cystic fibrosis (CF). The grant was awarded to Lorraine Martin, PhD, professor at Queen’s University Belfast, U.K. Martin is developing the therapy in collaboration with OmniSpirant Therapeutics. The…

Nearly two-thirds of the people with cystic fibrosis (CF) in the U.S. are under financial hardship, and many face unmet medical needs, meaning their treatment is not being addressed adequately. Researchers with George Washington University and the Cystic Fibrosis Foundation, who conducted this analysis into the cost of…

In-school use of airway clearance therapy (ACT) improved a number of health outcomes for children with cystic fibrosis (CF) who had poor adherence to ACT at home, according to a new study. In the year after starting ACT at school, the children experienced significant reductions in the number…