News

Teenagers and young adults with cystic fibrosis (CF) appear less likely to smoke cigarettes — tobacco or electronic — and marijuana than their peers, according to a U.S. study. Still, e-cigarette and marijuana use is not uncommon in this patient group, with 18- to 21-year-olds being most at risk. As…

Kaftrio, a combination of elexacaftor, tezacaftor, and ivacaftor marketed as Trikafta in the U.S., may relieve much of the discomfort that’s sometimes experienced by people with cystic fibrosis (CF) in the nose and the air-filled cavities around it, called sinuses, a German study found. The study, “Effects…

Pulmonary exacerbations in adults with cystic fibrosis (CF) fall into three distinct groups based on inflammatory markers in their bloodstream, a pilot study has discovered. These unique inflammatory profiles corresponded to different times from the onset of symptoms to hospitalization, to the rate of lung function decline before…

Cystic fibrosis (CF) patients with CF-related diabetes (CFRD) had a higher gastrointestinal (GI) symptom burden than patients who didn’t have it, a U.K. study found. CFRD patients had more symptoms related to appetite and gastroesophageal reflux disease (GERD), more commonly known as acid reflux or heartburn, as well…

The nonprofit Emily’s Entourage has awarded $220,000 to a project to develop a nonviral and inhalable gene therapy for cystic fibrosis (CF). The grant was awarded to Lorraine Martin, PhD, professor at Queen’s University Belfast, U.K. Martin is developing the therapy in collaboration with OmniSpirant Therapeutics. The…

Nearly two-thirds of the people with cystic fibrosis (CF) in the U.S. are under financial hardship, and many face unmet medical needs, meaning their treatment is not being addressed adequately. Researchers with George Washington University and the Cystic Fibrosis Foundation, who conducted this analysis into the cost of…

In-school use of airway clearance therapy (ACT) improved a number of health outcomes for children with cystic fibrosis (CF) who had poor adherence to ACT at home, according to a new study. In the year after starting ACT at school, the children experienced significant reductions in the number…

Type 2 diabetes in a 49-year-old woman with cystic fibrosis (CF) went into remission after bariatric surgery, given to help her lose weight after obesity was seen as the likely cause of her blood-sugar levels. She had a mild form of CF, stable pulmonary function and pancreatic sufficiency, supporting…

Taking Trikafta (elexacaftor/tezacaftor/ivacaftor) may lead to only a mild rise in liver enzymes in people with cystic fibrosis (CF)-related liver disease, a study found. This is likely not a clinically significant change, “and should not be a barrier to prescription,” the researchers wrote in the study, “Longitudinal effects…

A Phase 3 clinical trial called COPILOT, which will test the antibiotic ColiFin (inhaled colistimethate sodium) in people with cystic fibrosis (CF) who have chronic Pseudomonas aeruginosa lung infections, is expected to begin later this year. The trial is expected to enroll 38 adults and adolescents with moderate…