I wonder how you are faring now. Did the situation clear up?
I think there is not much to do about this, except being nice to the liver. So don’t burden it in other ways on top of the trikafta. No or little alcohol, not too much unsaturated fat etcetera. Many meds have this side effect by the way, among which are also some antibiotics. Accumulation might be avoided by chosing the right combinations.