News

People with cystic fibrosis-related diabetes (CFRD) show alterations in the lung microbiome, the community of microbes that live in the lungs, a study from Sweden found. These alterations are characterized by reduced diversity of bacterial types and more imbalanced bacterial composition. The study also demonstrated that patients with CFRD had…

Low- and ultra-low-dose lung CT scans may help monitor how people with cystic fibrosis (CF) respond to CFTR modulator therapies while using less radiation, a study in Italy suggests. After starting Trikafta (ivacaftor, tezacaftor, and elexacaftor), patients showed a nearly 50% reduction in airway thickening and a…

In 2018, when Nell Choi was 9 years old, she began experiencing symptoms that led to hospitalization and a diagnosis of neuromyelitis optica spectrum disorder (NMOSD), type positive. A month later, when Nell came home, she was weak, in a wheelchair, and had lost 20 pounds. To…

Among people with cystic fibrosis (CF) who develop kidney failure, getting a kidney transplant may extend survival by nearly two decades compared with other types of care, a new study found. The transplanted kidneys also showed favorable long-term outcomes in people with CF, remaining functional for about 7.2 years…

Both youngsters and teenagers with cystic fibrosis (CF) have abnormal levels of bile acids, the main components of the digestive fluid bile, in their blood compared with healthy children — and these alterations were found to worsen with age — a new study reports. The researchers also identified distinct…

The lungs of infants and children with cystic fibrosis (CF) show an early, overactive immune response driven by neutrophils — a type of immune cell — even in a patient receiving CFTR modulator therapy, a small study suggests. The findings suggest that inflammatory processes that damage the lungs may…

High-intensity interval training (HIIT), which alternates short periods of intense effort with equally short recovery periods, is safe and a feasible alternative to conventional training in adults with cystic fibrosis (CF), according to a small clinical trial in France. The trial demonstrated that adults with CF who completed 10…

Antiverse has entered into a research collaboration with the Cystic Fibrosis Foundation to develop novel antibodies targeting CFTR, the protein whose dysfunction causes cystic fibrosis (CF). The collaboration will specifically focus on designing antibodies that bind to the extracellular region of CFTR, the portion of the protein…

A smoking cessation program designed specifically for families of children with cystic fibrosis (CF) helped caregivers better understand the harms of smoke exposure, feel more confident about quitting, and reduce their cigarette use, according to a new study. The initiative, called Clinical Effort Against Smoke Exposure in Cystic Fibrosis (CEASE-CF),…

The European Medicines Agency (EMA) has awarded the early priority medicines designation, known as e-PRIME, to SPL84, an experimental inhalation therapy designed to treat cystic fibrosis (CF) caused by a specific mutation called 3849+10 kb C-to-T. The EMA grants e-PRIME to investigational medicines that target an unmet medical…