There could be many genes beyond CFTR that influence cystic fibrosis (CF) severity and treatment responses, according to a review study. Across 70 different studies, dozens of these so-called genetic modifiers were found to affect the severity of various CF symptoms. Mutations in a few of them were…
A study will explore why some people with cystic fibrosis (CF) respond better to Trikafta than others. The five-year study, led by Arkansas Children’s Research Institute, is being funded through a $2.9 million grant from the National Institutes of Health (NIH). The project is being led by Jennifer…
A clinical trial assessing the safety and tolerability of CMTX-101, an antibody-based therapy for cystic fibrosis (CF) lung infections, has started its second part. Phase 2a of the Phase 1b/2a trial (NCT06159725) aims to enroll up to 41 adults with CF at several sites in the U.S., treatment developer…
Chronic infection with the hepatitis E virus (HEV) may be linked to pig-derived pancreatic enzyme replacement therapy (PERT) in people with cystic fibrosis (CF) who underwent lung transplants, a study found. CF patients in general had disproportionately higher rates of antibodies against HEV, regardless of transplant status, and…
The abundance of Pseudomonas bacteria and related virulence factors in the lungs of people with cystic fibrosis (CF) after a transplant may raise their risk of a progressive decline in lung function and organ rejection, according to a recent study. Virulence is the ability of a microorganism to cause…
The 10th Annual Glow Ride for Cystic Fibrosis (CF), held Sept. 21 at Hermosa Beach, California, exceeded expectations by raising more than $65,700 to support families experiencing financial difficulties due to extended hospital stays. That’s according to Claire’s Place Foundation, a nonprofit that provides support to children with…
An agency of the National Institutes of Health has awarded funding up to $7 million to researchers at the University of California (UC) to study the use of probiotics to treat lung infections in people with cystic fibrosis (CF). The funding comes from the Advanced Research Projects Agency…
People with cystic fibrosis (CF) experience a more severe disease course when they continue to have a small hole between the heart’s upper chambers that fails to close naturally after birth, a study suggests. The hole, called patent foramen ovale (PFO), in CF patients was linked to more…
More gastroenterologists with expertise in cystic fibrosis (CF) are needed alongside registered dietitians to provide comprehensive patient care, a survey study has found. The survey of registered dietitians and gastroenterologists found the involvement of gastroenterologists in caring for CF patients varied widely across specialty centers, with barriers that included…
Bacterial ecotin has the potential to reduce lung damage in cystic fibrosis (CF) by inhibiting the activity of an enzyme called neutrophil elastase without affecting the immune system’s ability to fight off infections, researchers found. Because the findings come from a small number of patient samples, “future work will…
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