News

Changes in Airway Metabolites May Predict Likelihood of NTM Infection

Cystic fibrosis (CF) patients with non-tuberculous mycobacteria (NTM) lung infection show significant changes in airway metabolites relative to those without such infections, a study shows. Metabolites are intermediate or end products of cellular metabolism, and some of these altered metabolites play roles in immune responses and bacterial growth. Combining…

New Spectroscopy Method May Help Identify CF Bacteria Faster

Scientists at the University of Southampton have created a new method that could be useful for rapidly identifying infectious bacteria in samples from people with cystic fibrosis (CF). Unlike currently used methods, this method does not require a time-consuming culture step where bacteria are grown in a laboratory. The…

Some Severe Asthma Patients Carry CFTR Variants: Genetic Study

Some people with severe asthma, an inflammatory lung condition, carry variants of the CFTR gene that causes cystic fibrosis (CF), a genetic study found. These findings support the genetic assessment of severe asthma patients with CF-related symptoms, the scientists recommended. The study, “DNA Sequencing Analysis of…

Targeting Pathway With Ectoine May Help in Stabilizing CFTR Protein

A natural compound called ectoine may help to improve the stability of the CFTR protein by modulating the activity of a molecular signaling pathway called AREG-EGFR-ERK, a study reported. Ectoine is a stress-protection molecule with water-retaining and potentially anti-inflammatory properties. The researchers suggested that ectoine, given in combination with CFTR…

CF-370 Reduces Hard-to-treat Bacteria in Rabbit Model

CF-370, an expeimental therapy by ContraFect, reduces the number of hard-to-treat Pseudomonas aeruginosa bacteria in a rabbit model of pneumonia, an infection that inflames the lungs. P. aeruginosa, the most common cause of lung infections in people with cystic fibrosis (CF), can evade the body’s immune…

Fundraising, Education, Conferences Planned for CF Awareness Month

Patients, family, friends, and caregivers will come together this May for Cystic Fibrosis (CF) Awareness Month to educate the public about the condition and raise money for research and care. A number of CF organizations have events planned throughout the month, including the largest U.S.-based nonprofit, the Cystic Fibrosis…

CFF Awards Research Grant to College Sophomore

Inspired by a cousin who lives with cystic fibrosis (CF), a University of Central Florida (UCF) undergraduate student will use a $4,000 Cystic Fibrosis Foundation (CFF) grant to seek better treatments for the genetic disease that affects the lungs and other organs. The young researcher, Sahiba Ahmed,…