People with cystic fibrosis (CF) have higher levels of DNA from common microbes that cause CF-related infections circulating in their blood compared to healthy controls, a study discovered. These findings support the development of a simple blood test as a noninvasive…
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The nonprofit group OneLegacy has launched a video series, available on its social media channels, to raise awareness of the importance of organ and tissue donations. Called “Sound Good?” the four-part series features the stories of two teenagers and high school friends, one who is struggling with heart disease and…
In addition to restoring CFTR protein function in cells, the cystic fibrosis (CF) therapies Orkambi (lumacaftor/ivacaftor) and Symdeko (tezacaftor/ivacaftor combo) significantly reduce the excessive inflammation that damages patients’ lungs, a recent study suggests. Symdeko seems to be more potent than Orkambi at dampening inflammatory responses.
Oxford Hospitals Charity has purchased and delivered machines able to measure lung function at home to 120 young patients with cystic fibrosis (CF) in the U.K., enabling them to closely monitor their condition during the COVID-19 pandemic. The mini lung function machines were funded with the…
Dara Riva always had a rule that her 10-year-old son could play video games only once a week. But then the COVID-19 pandemic struck, and her perspective changed. Riva’s son, Maximilian, has cystic fibrosis (CF), making him particularly susceptible to COVID-19 and the complications that can arise from it.
Antibiotic susceptibility tests that determine how people with lung infections will respond to antibiotics may work better if researchers grow the pathogenic bacteria in the lab along with other commensal bacteria found in the lungs, because it more accurately mimics their real environment, a recent study suggests. The reason for…
The antibiotic-resistant bacterium Stenotrophomonas maltophilia, a dangerous bacteria for people with lung diseases such as cystic fibrosis (CF), is widely spread around the world, with most strains carrying virulence and resistance genes, a large genetic study shows. The study, “The phylogenetic landscape and nosocomial spread of…
Researchers identified a biochemical mechanism that regulates the thickness of mucus, and could serve as a target of new treatments for chronic respiratory illnesses that include cystic fibrosis (CF). The study, “Trefoil factors share a lectin activity that defines their role in mucus,” was published in the journal …
While the COVID-19 outbreak has turned Cystic Fibrosis Foundation (CFF) activities into online events, Cystic Fibrosis Awareness Month continues to move forward, and with an emphasis on patient stories and education. Observed each May, the month is set aside to raise support and awareness for cystic fibrosis (CF), an…
A potential gene therapy for cystic fibrosis, KB407, is able to induce the expression of normal CFTR protein in cell models of CF, its developer, Krystal Biotech, reports. These data are in the poster, “In vitro Pharmacology of KB407, an HSV-1 based gene therapy vector,…
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