News

A number of important discoveries, therapeutic developments, and events related to cystic fibrosis (CF) were reported daily by Cystic Fibrosis News Today throughout 2016. Now that the year is over, it is time to briefly review the articles that appealed most to our readers. Here are the top 10 most-read…

Although patients with cystic fibrosis (CF) often have low levels of the antioxidant glutathione (GSH), the clinical benefits of GSH as an inhaled therapy appear to depend on the inflammatory status of their airways. The study, “Increasing sputum levels of gamma-glutamyltransferase may identify cystic fibrosis patients who do not…

Galapagos NV recently reported positive topline results from SAPHIRA 1, a Phase 2 clinical trial assessing the company’s potentiator molecule, GLPG1837, in patients with cystic fibrosis (CF) who have the G551D mutation. Data showed results comparable to an approved CF treatment, the company announced. SAPHIRA 1 (NCT02707562) was an…

Pregnant women with cystic fibrosis (CF) are more likely to develop diabetes and deliver prematurely by cesarean than other women, a retrospective study reports. They are also more likely to have babies with birth anomalies,  although not necessarily life-altering ones. The study, “Maternal co-morbidities and neonatal outcomes associated with…

The bacteria Pseudomonas aeruginosa, which settle in the lungs of most cystic fibrosis (CF) patients, destroy the lungs by perpetuating the inflammation that aims to control invading microbes, according to a study. This contra-intuitive finding demonstrates the power of the mechanisms bacteria use to gain a survival advantage. It also…

In a small randomized clinical trial, researchers at Karolinska Institute in Sweden showed that vitamin D supplements may improve lung function in cystic fibrosis (CF) patients. A daily intake of high levels of vitamin D are required, however, for the effects to be noticed. The study, “Clinical…

People with more severe cystic fibrosis-causing gene mutations tend to have poorer mental health as they age, an effect mediated entirely by their worsening lung health, according to a recent analysis. While exercise was seen to improve the mental health of these patients, it was effective only if it improved…

A recent study reported experiences and perceptions among parents whose children have been diagnosed with cystic fibrosis (CF) or sickle cell disease (SCD) via the newborn screening (NBS) program in the United Kingdom. Not surprisingly, the results showed that a positive NBS result may have a profound psychosocial impact on parents,…

Researchers may have come one step closer to more effective treatments against Pseudomonas aeruginosa growing in layers known as harmful biofilms. A compound found in soil bacteria prevented the bacteria from forming biofilms, which is a serious health threat to patients with cystic fibrosis. The findings, published in the journal…

Under a research contract award granted by the Cystic Fibrosis Foundation Therapeutics (CFFT), Matinas BioPharma and the Colorado State University (CSU) will jointly conduct preclinical studies assessing the efficacy of MAT2501, a potential oral antibiotic, in treating nontuberculous mycobacterium infection (NTM) in a cystic fibrosis (CF) lung model.