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Changes in two human voice parameters may help identify poor control of blood sugar levels in people with cystic fibrosis (CF) who have CF-related diabetes (CFRD), a pilot study reported. Lower measures on these parameters, known as fundamental frequency variation and noise-to-harmonic ratio, were linked with higher glucose,…

For people with cystic fibrosis (CF), key barriers to getting specialty care include concerns about addiction and affordability, according to a new survey of clinicians. In fact, more than one-third of respondents cited difficulties for CF patients in accessing specialists and issues with insurance and treatment costs. “In this…

For people with cystic fibrosis (CF) taking Pulmozyme (dornase alfa), adding treatment with hypertonic saline — or HS for short — did not significantly improve lung function or reduce the risk of exacerbations compared with the approved therapy alone, a new study indicates. The findings showed that…

Kaftrio (elexacaftor, tezacaftor, and ivacaftor) safely and effectively eases structural lung damage and improves lung function and the quality of life for people with cystic fibrosis (CF) who have advanced lung disease. That’s according to data from a compassionate use program in the Netherlands that let patients with severely…

Men with cystic fibrosis (CF) saw greater reductions in lung symptom exacerbations after starting treatment with Trikafta (elexacaftor/tezacaftor/ivacaftor) than their female counterparts, according to a recent study. Changes in nutritional status, lung infections, and lung function were similar between the sexes. The findings overall suggest that high-efficacy therapies…

Among children with cystic fibrosis (CF), lung function was seen to worsen faster following a bacterial infection with Pseudomonas aeruginosa, especially if the infection became chronic or ongoing, a new study reports. The link between the bacterium — commonly known as Pseudomonas or P. aeruginosa — and a…

Antibiotic resistance is high among cystic fibrosis (CF) patients infected with Staphylococcus aureus (S. aureus), according to a recent study. There was “high resistance to most of the antibiotics studied,” researchers say, with the highest observed for the antibiotics erythromycin and clindamycin, while the lowest resistance was seen with…

TAVT-135, an inhaled treatment candidate being developed for people with cystic fibrosis (CF) regardless of their underlying mutation type, was found to help normalize mucus production in a cell model of the disease. According to researchers from Tavanta Therapeutics, the treatment’s developer, the findings of their in vitro…

Scientists in New York are calling on the cystic fibrosis (CF) research community to take proactive steps to increase diversity in clinical trials — which now typically include a disproportionate number of non-Hispanic white people, and fewer patients from other racial and ethnic backgrounds. “Ensuring that pwCF [people with…

Reducing the dose of Kaftrio (elexacaftor, tezacaftor, and ivacaftor) should be considered for cystic fibrosis (CF) patients who report cognitive and psychological side effects, a study in Ireland suggests. Such patients should have an individualized dosage to minimize side effects while maintaining CFTR modulator therapy. “Dose reduction…