News

As it has done for decades, AbbVie is seeking applications from U.S. cystic fibrosis (CF) patients for its latest round of college scholarships. Eligible undergraduate and graduate students may apply online or by mail through 11 a.m. ET May 24 for an AbbVie Cystic Fibrosis Scholarship…

Among women with cystic fibrosis (CF) who experienced a pregnancy, those that were unplanned were associated with an increased frequency of pulmonary exacerbations after giving birth, according to a recent study. Regardless of whether the pregnancy was planned or unplanned, women experienced declines in lung function after delivery compared…

As pregnancy becomes more common among women with cystic fibrosis (CF), and more CF patients are becoming parents, there is a pressing need for CF clinics to incorporate discussions about reproductive health — with a focus on pregnant women — into routine care, a new study highlights. “As the…

Health Canada has extended its approval of Orkambi (lumacaftor/ivacaftor) to treat children as young as 1 who have cystic fibrosis (CF) caused by two copies of the F508del mutation. With this approval, about 30 children in Canada are expected to gain access to treatment that…

Chemical signaling within the protective clusters formed by Pseudomonas aeruginosa — a common infection-causing bacteria in cystic fibrosis (CF) — is dependent on factors such as surface type, the presence of antibiotics, and the bacterial strain, a study found. Such infections in CF are often resistant to standard…

Treatment with Orkambi (lumacaftor/ivacaftor) for six months lessened airway inflammation and enhanced airway bacterial diversity in people with cystic fibrosis (CF), but only when administered before patients were chronically infected with the bacterium Pseudomonas aeruginosa, a study has found. The findings suggest that “CFTR modulators [such as Orkambi] should…

Lung function decline in adults with stable cystic fibrosis (CF) was tied to high numbers of mature low-density neutrophils, a white blood cell subtype associated with inflammatory disorders, a study suggests. While previous research showed that low-density neutrophils in CF children correlated with better lung function, the changes found…

The Cystic Fibrosis Foundation (CFF) is investing up to $15.5 million in Anagram Therapeutics to conduct early-stage trials of a new oral enzyme replacement therapy. The company is planning to start a Phase 1 clinical trial this summer. The therapy would let people with cystic fibrosis (CF)…

Pulmonary exacerbations in children with cystic fibrosis (CF) caused by multiple bacteria (polymicrobial) are generally treated with antibiotics that cover all the bacteria detected, a study reported. Whether this strategy is associated with better clinical outcomes than using antibiotics that cover only some of the detected bacteria remains to…

In a small clinical trial, Orkambi (lumacaftor/ivacaftor) appeared to reduce structural damage in the lungs, as measured by a chest MRI, for preschool-age children with cystic fibrosis (CF) who are homozygous for the F508del mutation. “This study suggests that [Orkambi] may modify CF disease progression when administered early…