News

Airway Clearance Physiotherapy Can Ease CF Respiratory Symptoms

Twice-weekly sessions of airway clearance physiotherapy over eight weeks led to clinically meaningful reductions in respiratory symptoms in people with cystic fibrosis (CF) in a small clinical trial. These preliminary findings, based on patient-reported measures, support the need for further studies to determine the most effective airway clearance technique,…

Inhaled Nanoparticles Could Help Lung CFTR Production, Study Says

Researchers in Oregon have developed lipid nanoparticles that can be inhaled and effectively deliver messenger ribonucleic acid (mRNA) into the lungs of mice, triggering the cells to produce the defective protein in cystic fibrosis (CF). “Inhaled [lipid nanoparticles] resulted in localized protein production in the mouse lung without toxicity,…

Colorectal Cancer Risk 5-times Higher in CF: Population Study

The incidence of colorectal cancer (CRC) in people with cystic fibrosis (CF) was five times higher than in those without CF, after adjusting for age, in a large-scale English population study. CFTR gene mutations, the underlying cause of CF, occurred more frequently than expected, suggesting an association between…

GERD Treatment May Raise the Risk of Respiratory Infection: Study

Prolonged use of certain medications used to treat acid reflux, called proton pump inhibitors (PPIs), may put people with cystic fibrosis (CF) at higher risk for Pseudomonas aeruginosa infection, according to a single-center study in Italy. Long-term treatment was also associated with more hospitalizations for pulmonary exacerbations, or episodes of…

Worse CF Detection in Genetic Screening for US Ethnic Groups

Newborn genetic screening panels for variants in the CFTR gene — mutations of which are the underlying cause of cystic fibrosis (CF) — had lower detection rates in minority racial and ethnic groups in the U.S., a large-scale analysis found. Lower detection rates with genetic testing among these…