Wrinkling on the palm of the hands after a short immersion in water may serve as a fast, easy and inexpensive test for an initial diagnosis of cystic fibrosis (CF), a study reports. Compared to healthy children in this study, those with CF developed signs of palm wrinkling — swelling,…
Inflammation in the airways of people with cystic fibrosis (CF) regulates the pH of the surface liquid and increases the response to approved CFTR modulators, a cell-based study suggested. Airway inflammation may be a key determinant in response to CF medicines, the researchers noted. “To advance personalized CFTR…
To examine the socioeconomic impact of cystic fibrosis (CF) on patients, caregivers, and society, Cystic Fibrosis Canada (CF Canada) is partnering for a questionnaire study with The Conference Board of Canada. CF patients and caregivers across Canada wanting in taking part in this research, called “The Social…
During adolescence and young adulthood, healthy siblings of cystic fibrosis (CF) patients have to find ways to achieve a balance between the illness of their brother or sister, family organization, and their own needs, a small study in Italy reported. Coping strategies included dampening emotional awareness, normalizing their life…
Eloxx Pharmaceuticals announced it expects to share data later this year from the first four treatment groups of a Phase 2 program evaluating the investigational therapy ELX-02 in people with cystic fibrosis (CF) who have at least one G542X mutation. “Given the substantial efforts of our clinical team,…
Functional residual capacity (FRC), a measure of the volume of air left in the lungs at the end of a normal exhalation, may help detect lung disease in children diagnosed with cystic fibrosis (CF) via newborn screening, a study suggests. Also, a cut-off value of 36 breaths per minute may…
Arrowhead Pharmaceuticals has voluntarily paused new screening, enrollment, and dosing in its Phase 1/2 trial of ARO-ENaC, an investigational treatment for cystic fibrosis (CF). The decision came after unexpected signs of local lung inflammation occurred in an ongoing chronic toxicology study taking place in rats. “The safety of…
Cystic fibrosis (CF) patients with specific variants in the Tensin 1 gene may be at risk of low body mass index (BMI), a measure of nutritional status, if they carry the common CF-causing F508del mutation in both copies of the CFTR gene, a study reports. This makes Tensin 1 (TNS1) a…
Cystic fibrosis (CF) patients with lower aerobic exercise capacity — assessed with a non-invasive cardiopulmonary exercise test — have a 4.5 times higher risk of future pulmonary exacerbations, according to a small 10-year study in Greece. Aerobic capacity, or VO2peak, is the maximal amount of oxygen a person’s…
At its first virtual investor event, biotech company Centogene set a bold mission: to cure 100 rare diseases within the next decade. A leader in the field of genetic diagnostics, Centogene used the June 22 event to present its strategic priorities, outlining its plans to speed the discovery…
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