CF, Depression and Anxiety
Persons with CF (pwCF) have a long history of depression and anxiety. There are so many reasons why this is so -anxiety about what tomorrow may bring, deteriorating health, being a burden being just a few.
The faulty CFTR Chloride channel may be expected to lead to higher Chloride in the intracellular environment which may be expected to be balanced by increased cationic electrolytes such as Potassium (K), Sodium (Na) and Calcium (Ca). Electrolytes are involved in the transmission of impulses along the axons of nerves. How do increased levels of these electrolytes in nerve cells affect their function? Lithium is used in the treatment of Bipolar disease – does it work by reducing other intracellular cations?
Is abnormal intracellular electrolytes a contributing factor in depression and anxiety in pwCF?
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