ProMetic Life Sciences Inc. announced plans to initiate a Phase 2 clinical trial to test its anti-fibrotic lead drug candidate PBI-4050 in cystic fibrosis (CF) patients with related diabetes as well as liver steatosis. Cystic fibrosis is a chronic disease of the lungs and, less frequently, of the pancreas, liver, kidneys, and gut,…
cystic fibrosis
Ryan Kelly has been named the 17th football player to win the 2015 Rimington Trophy. The award, which was announced last Thursday on December 10 according to a recent press release, is given annually to the Most Outstanding Center in NCAA Division I-A College Football in the U.S., and is determined by a consensus of All-American…
New complexes of nickel (II) with imidazole derivatives were evaluated as potential treatment for P. aeruginosa biofilm eradication in cystic fibrosis. The study, titled “The effects of nickel(II) complexes with imidazole derivatives on pyocyanin and pyoverdine production by Pseudomonas aeruginosa strains isolated from cystic fibrosis” was published…
In a new study, researchers describe the results of a genome-wide screen of Pseudomonas aeruginosa in a yeast, which led to the identification of three potential new Pseudomonas virulence factors. The research paper, entitled “Genome-wide Screen of Pseudomonas aeruginosa in Saccharomyces cerevisiae Identifies New Virulence Factors,” was published in Frontiers in Cellular and…
Luanne McKinnon, like many cystic fibrosis (CF) patients, is a determined achiever who lives life to its fullest — even earning a doctorate in art history at age 60. Her story was the subject of a recent profile in The University of Virginia’s online newspaper, UVA Today. McKinnon, who was awarded her PhD…
Nivalis Therapeutics, Inc., a Boulder, Colorado-based clinical stage pharmaceutical company, announced that the first patient has been dosed in the Phase 2 clinical trial of its lead investigational drug, N91115, a stabilizer of the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The purpose of this double-blind, randomized, placebo-controlled, parallel group study…
Protein interactions could be misdirected in people with cystic fibrosis (CF), causing a loss of normal protein function, according to researchers from the Scripps Research Institute (TSRI) in San Diego, California. The new study, titled “∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis“ appeared online on Nov. 30, 2015, ahead…
The Cystic Fibrosis Foundation’s 2015 Ultimate Golf Experience, which ran four days beginning on Oct. 21, raised $630,000 towards continuing the organization’s mission of promoting disease research and awareness. Over 200 people attended the tournament at the Ritz-Carlton Dove Mountain resort in Tucson, Arizona. The event was hailed as a success and a source of much-needed…
Ever since High Frequency Chest Wall Oscillation (HFCWO) devices were developed to help patients with cystic fibrosis breathe easier, clinical researchers required appropriate parameters to assess the efficacy of HFCWO-based therapies. It is common practice to look at three main indicators of pulmonary and overall health: mucus clearance,…
A new cystic fibrosis study, showing a high-resolution picture of the fungal microbiome of cystic fibrosis patients’ lungs, has identified a genetic basis for pathogen adaptation in a fungus exposed to bacteria. The study, entitled “Global Analysis of the Fungal Microbiome in Cystic Fibrosis Patients Reveals Loss of Function of…
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