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Cystic fibrosis (CF) likely affects as many babies in parts of Asia, Africa, and South America as in Europe and the U.S., and better genetic testing and broader access to effective treatments are urgently needed worldwide, a study suggests. The study, “Analysis of the Genome Aggregation Database (gnomAD)…

Scientists have developed a more precise version of a gene-editing tool, showing that it can correct mutations that cause cystic fibrosis (CF) in cell models and also introduce CF-causing mutations into cells for research. “We were able to introduce specific cystic-fibrosis mutations into human epithelial cells relevant to the…

Long-term exposure to fine particulate matter, a type of air pollution, accelerates the decline in lung function among people with cystic fibrosis (CF) living certain areas of London, according to a new study. The research showed that CF patients exposed to higher levels of fine particulate matter experienced significantly…

Researchers at UCLA have developed a nonviral gene-editing strategy that could help pave the way for one-time treatments for people with cystic fibrosis (CF). The experimental therapy uses lipid nanoparticles — tiny fatty molecules — to insert a full, healthy copy of the CFTR gene into human airway cells,…

Routine blood tests can accurately predict the development of an allergic response to the fungus Aspergillus in children with cystic fibrosis (CF), a study suggests. A higher risk of the lung allergic response, called allergic bronchopulmonary aspergillosis (ABPA), was found among those with elevated biomarker levels for up…

Children with cystic fibrosis (CF) have lower gut levels of certain short-chain fatty acids (SCFAs), metabolites made by beneficial gut bacteria that help regulate inflammation, a study reports. The researchers also found that children with CF had lower dietary fiber intake, reduced gut microbial diversity, fewer key SCFA-producing bacteria,…

Handgrip strength was associated with breathing muscle strength in adults with cystic fibrosis (CF), according to a new study, suggesting the simple test may help complement standard lung function tests in clinical care. The research also found that lung function and breathing muscle strength were related to a combination…

Short-term increases in air pollution can trigger pulmonary exacerbations — disease flares marked by a sudden worsening in lung function — in people with cystic fibrosis (CF), a new study shows. Notably, the study found that increased pollution doesn’t trigger exacerbations right away — the data suggest that…

Treatment with Trikafta (elexacaftor/tezacaftor/ivacaftor) may do more than improve the function of a faulty protein in people with cystic fibrosis (CF). According to a new study from Italy, the triple-combination therapy may also help reduce chronic inflammation, known to contribute to long-term lung damage in those with CF.

The amount of physical activity children and adolescents with cystic fibrosis (CF) get is linked to their age, physical abilities, screen time, and several other everyday factors, according to a recent study. Other factors tied to physical activity included taking part in organized sports, having social support from others,…