Levels in the bloodstream of certain circulating microRNAs — small strands of genetic material that help regulate gene activity — may flag changes linked to cystic fibrosis-related diabetes (CFRD), or its development, in people with cystic fibrosis (CF). That’s according to a new study by researchers in Europe…
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About one-quarter of children with cystic fibrosis (CF) who are hospitalized for pulmonary exacerbations — an acute worsening of lung symptoms, often marked by increased cough and thicker or more mucus — will temporarily develop pulmonary hypertension (PH), a condition marked by high pressure in blood vessels that…
Kidney failure, when the kidneys no longer work on their own, is up to 29 times more common in people with cystic fibrosis (CF) than in the general U.S. population. That’s according to a recent study, which also identified diabetes and complications associated with lung transplant as the most…
Trikafta safely improved lung function and reduced exacerbations in people with cystic fibrosis (CF) who started treatment after age 40, a study found. Some participants no longer had Pseudomonas aeruginosa or methicillin-resistant Staphylococcus aureus (MRSA), bacteria that are major contributors to CF lung disease. “Overall, our study…
Packaging fat-soluble vitamins in orally available nanomicelles, or tiny vesicles that enhance drug delivery, improves absorption into the bloodstream and clinical outcomes in people with cystic fibrosis (CF) compared with standard oral supplementation, according to a clinical trial. Fat-soluble vitamins include vitamins A, D, and E. “This delivery…
Treatment with Kaftrio may reduce the need for salt supplementation to treat salt wasting, the excessive loss of sodium and chloride in sweat that occurs in people with cystic fibrosis (CF), a new study reports. Kaftrio (elexacaftor/tezacaftor/ivacaftor), sold as Trikafta in the U.S., restored electrolyte (salt) balance, as indicated…
Adults with cystic fibrosis (CF) who are better at coping with their thoughts and feelings also achieve greater well-being, with mindfulness — especially acting with awareness — partially explaining this link to better mental health, a new U.K. study found. According to the researchers, the results suggest that interventions…
Treatment with Alyftrek, a combination of vanzacaftor, tezacaftor, and deutivacaftor, led to better patient-reported health-related quality of life for children, adolescents, and adults with cystic fibrosis (CF), a study found. The benefits were greater than those achieved with Trikafta (elexacaftor/tezacaftor/ivacaftor), according to a post-hoc analysis of three…
CMTX-101, an antibody-based therapy designed to help clear bacterial lung infections, was tolerated well among people with cystic fibrosis (CF) in an early clinical trial. Developer Clarametyx Biosciences said trial data also suggest the experimental therapy may help decrease inflammation and reduce counts of infectious bacteria. “The strong results…
An experimental inhaled gene therapy for cystic fibrosis (CF), is headed for advanced clinical testing following Phase 1 data that indicated it’s generally tolerated well and appears to be working as designed. KB407 developer Krystal Biotech recently announced interim data from the CORAL-1 (NCT05504837), a Phase 1…
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