High-intensity interval training (HIIT), which alternates short periods of intense effort with equally short recovery periods, is safe and a feasible alternative to conventional training in adults with cystic fibrosis (CF), according to a small clinical trial in France. The trial demonstrated that adults with CF who completed 10…
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Antiverse has entered into a research collaboration with the Cystic Fibrosis Foundation to develop novel antibodies targeting CFTR, the protein whose dysfunction causes cystic fibrosis (CF). The collaboration will specifically focus on designing antibodies that bind to the extracellular region of CFTR, the portion of the protein…
A smoking cessation program designed specifically for families of children with cystic fibrosis (CF) helped caregivers better understand the harms of smoke exposure, feel more confident about quitting, and reduce their cigarette use, according to a new study. The initiative, called Clinical Effort Against Smoke Exposure in Cystic Fibrosis (CEASE-CF),…
The European Medicines Agency (EMA) has awarded the early priority medicines designation, known as e-PRIME, to SPL84, an experimental inhalation therapy designed to treat cystic fibrosis (CF) caused by a specific mutation called 3849+10 kb C-to-T. The EMA grants e-PRIME to investigational medicines that target an unmet medical…
One year of treatment with Trikafta modestly eased some digestive symptoms and led to fewer reports of constipation in children with cystic fibrosis (CF), although those were already low before the triple-combination therapy, a new study reports. It also increased the proportion of patients with normal levels of fecal…
Lower insulin doses and less blood sugar variability were observed one year after adults with cystic fibrosis-related diabetes (CFRD) started Kaftrio. That’s according to results from the DIATRIM study (NCT06331000), a real-world, multicenter observational study conducted at 13 centers in France. Researchers retrospectively analyzed data from adults with…
Cystic fibrosis (CF) likely affects as many babies in parts of Asia, Africa, and South America as in Europe and the U.S., and better genetic testing and broader access to effective treatments are urgently needed worldwide, a study suggests. The study, “Analysis of the Genome Aggregation Database (gnomAD)…
Scientists have developed a more precise version of a gene-editing tool, showing that it can correct mutations that cause cystic fibrosis (CF) in cell models and also introduce CF-causing mutations into cells for research. “We were able to introduce specific cystic-fibrosis mutations into human epithelial cells relevant to the…
Long-term exposure to fine particulate matter, a type of air pollution, accelerates the decline in lung function among people with cystic fibrosis (CF) living certain areas of London, according to a new study. The research showed that CF patients exposed to higher levels of fine particulate matter experienced significantly…
Researchers at UCLA have developed a nonviral gene-editing strategy that could help pave the way for one-time treatments for people with cystic fibrosis (CF). The experimental therapy uses lipid nanoparticles — tiny fatty molecules — to insert a full, healthy copy of the CFTR gene into human airway cells,…
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