News

An independent data monitoring committee, following a safety review, recommended that a Phase 2 trial of BX004, Biomx’s experimental treatment for Pseudomonas aeruginosa infection in people with cystic fibrosis (CF), continue with revised dosing. Although Europe’s part of the study is advancing, the U.S. Food and Drug Administration (FDA)…

Adults with cystic fibrosis (CF) who are not eligible for Kaftrio therapy reported feeling forgotten in both the media and research, with conflicting emotions about those who do benefit from the approved treatment, according to a new interview-based study by researchers in the U.K. Study participants noted that…

People with cystic fibrosis (CF) who have certain lung structure abnormalities — ones visible on CT scans — are more likely than those with other issues also seen via imaging to experience improvements in lung function after starting treatment with Trikafta. That’s according to the results of a new analysis…

The U.S. Food and Drug Administration (FDA) has cleared the start of the third part of a Phase 2 clinical trial testing RCT2100, Recode Therapeutics’ investigational treatment for cystic fibrosis (CF). This portion of the Phase 2 trial (NCT06237335) will test RCT2100 together with Kalydeco (ivacaftor) in…

Six months of treatment with Trikafta (elexacaftor/tezacaftor/ivacaftor) helped open the nasal and sinus passages in people with cystic fibrosis (CF), a study reports. For many people with CF, these passages — which make up the sinonasal cavity — often become inflamed or develop growths and infections. Treatment with…

The U.S. approval of CFTR modulators for cystic fibrosis (CF) may have reduced or delayed the need for liver transplants among people in the country with CF-related liver disease, or CFrLD, a new study suggests. Since the U.S. Food and Drug Administration (FDA) approved Trikafta (elexacaftor/tezacaftor/ivacaftor) — the first…

Researchers in Italy have developed a new experimental compound called 3b, which has shown early promise as a dual-action therapy for cystic fibrosis (CF). It addresses the dysfunction of the CFTR protein that causes the disease, as well as protects against viral threats that can worsen lung problems. In…

The U.S. Food and Drug Administration (FDA) has approved a new generic form of inhaled tobramycin, an antibiotic that’s used to treat bacterial lung infections in people with cystic fibrosis (CF). The newly approved therapy, tobramycin inhalation solution, will be sold by The Ritedose Corporation through its…

Vertex Pharmaceuticals presented new data highlighting additional clinical benefits and improved outcomes in people with cystic fibrosis (CF) treated with the triple combination Alyftrek (vanzacaftor/tezacaftor/deutivacaftor) or other CFTR modulators. The data also suggest that Alyftrek may lead to fewer pulmonary exacerbations (flare-ups) and less antibiotic usage than…

Sionna Therapeutics has launched a clinical trial to test its experimental therapy SION-719 in combination with Trikafta (elexacaftor/tezacaftor/ivacaftor), which is currently the standard-of-care treatment for cystic fibrosis (CF). According to a company press release, the Phase 2a study (NCT07108153) will enroll adults with CF who…