An agency of the National Institutes of Health has awarded funding up to $7 million to researchers at the University of California (UC) to study the use of probiotics to treat lung infections in people with cystic fibrosis (CF). The funding comes from the Advanced Research Projects Agency…
People with cystic fibrosis (CF) experience a more severe disease course when they continue to have a small hole between the heart’s upper chambers that fails to close naturally after birth, a study suggests. The hole, called patent foramen ovale (PFO), in CF patients was linked to more…
More gastroenterologists with expertise in cystic fibrosis (CF) are needed alongside registered dietitians to provide comprehensive patient care, a survey study has found. The survey of registered dietitians and gastroenterologists found the involvement of gastroenterologists in caring for CF patients varied widely across specialty centers, with barriers that included…
Bacterial ecotin has the potential to reduce lung damage in cystic fibrosis (CF) by inhibiting the activity of an enzyme called neutrophil elastase without affecting the immune system’s ability to fight off infections, researchers found. Because the findings come from a small number of patient samples, “future work will…
Cells from the lungs of people with cystic fibrosis (CF) are less susceptible to infection by SARS-CoV-2, the COVID-19-causing virus, than those of people with other lung diseases, but they respond similarly to the influenza A virus, a study found. Restoring function to CFTR, the protein that’s faulty or…
The immune system of people with cystic fibrosis (CF) might be impaired due to long-term persistent lung infections and inflammation, a study suggested. Using a new and noninvasive standardized test for immune function called TruCulture, scientists found a lesser release of certain immune signaling proteins in immune cells from…
A new Cystic Fibrosis Innovation Hub has been launched in the U.K. to accelerate the development of new tests and treatments for lung infections in cystic fibrosis (CF) patients. This University of Liverpool-based hub will join a Translational Innovation Hub Network, which includes hubs led by the University of…
The balance of acids and bases in the urine of people with cystic fibrosis (CF) reflects lung and pancreas function, and the response to treatment, a study finds. The findings support measuring the bicarbonate base in urine, which mirrors the levels of various acids, as a tool to clinically…
A Phase 1b study that’s evaluating the safety of RCT2100, ReCode Therapeutics‘ investigational genetic medicine for people with cystic fibrosis (CF), has dosed its first patient. The inhalation therapy is being developed for CF patients who don’t respond to CFTR modulator therapies. “The initiation of our Phase…
A next-generation vest to help clear airway mucus in adults and children with cystic fibrosis (CF) or other lung disorders has been launched by its maker, Baxter International. Called The Vest Advanced Pulmonary Experience (APX), the garment was redesigned in consultation with clinicians and patients, and incorporates the…
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