News

Treatment with CFTR modulators was safe during pregnancy and breastfeeding in two women with cystic fibrosis (CF), according to a recent report. Despite being advised to stop treatment, both women continued on their CFTR modulator during pregnancy and breastfeeding without any safety concerns. According to the researchers, this…

Treatment with Trikafta improved insulin secretion and body weight within one year in people with cystic fibrosis (CF), according to a small analysis. Despite these findings, there were no consistent treatment-related improvements in measures relating to CF-related diabetes, or CFRD, a common complication among children and adults…

The Phase 1b/2a clinical trial SWARM–Pa, testing Armata Pharmaceuticals‘ experimental phage therapy AP-PA02 in people with cystic fibrosis (CF) who have chronic Pseudomonas aeruginosa infections, is complete, Armata announced. Data will now be analyzed, and top-line results are expected early in the new year. “We are very pleased to…

Claire’s Place Foundation has announced the launch of its fundraising campaign, called #CPFoneinamillion, to support families with cystic fibrosis (CF) during extended hospital stays. Since its founding in 2011, the nonprofit has given $875,000 in Extended Hospital Stay Grants to people affected by CF. The new…

Women with cystic fibrosis (CF) who had a lung transplant are at higher risk of testing positive for the human papillomavirus (HPV), a virus that can cause many cancers, a French study found. Researchers also observed that it was more common for these women than for the general population…

The levels of fecal calprotectin protein increase during pulmonary exacerbations — times when respiratory symptoms suddenly worsen — then drop within two weeks of systemic antibiotic treatment given children and adolescents with cystic fibrosis (CF), a study from Iran reported. “Fecal calprotectin level could be considered as a…

Trikafta (elexacaftor/tezacaftor/ivacaftor) improved lung function and reduced inflammation throughout the body over six months in patients with cystic fibrosis (CF), a new study reports. Treatment with the triple-combination therapy also reduced detection of Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus, or MRSA, two harmful bacteria that can cause…

Researchers have discovered that monocytes, a type of white blood cell, drive persistent and sustained inflammation that leads to lung damage in people with cystic fibrosis (CF), a study reported. The researchers showed that, in a CF mouse model, reducing monocyte activity lowered the number of tissue-damaging immune cells…

SpliSense has launched a Phase 1/2 clinical trial to test SPL84, its inhaled treatment candidate for cystic fibrosis (CF) patients carrying a common disease-causing splicing mutation. As of now, no specific treatment is available for people with CF who carry this particular mutation. Called 3849+10 kb C-to-T, it…

The Cystic Fibrosis Foundation has invested another $4.85 million — termed an equity investment — in Aridis Pharmaceuticals to advance the clinical development of AR-501, an inhaled treatment for chronic lung infections in people with cystic fibrosis (CF). The total funding from the CF Foundation for the clinical…