News

People with cystic fibrosis (CF) who had a liver transplant can be safely started on Trikafta (elexacaftor/tezacaftor/ivacaftor), a small study suggests. For most patients in the study, Trikafta’s use resulted in an easing of symptoms, better quality of life, and healthier body weight and lung function. Doctors with…

People in the U.K. at highest risk of becoming seriously ill from COVID-19 — including those with cystic fibrosis (CF) — starting on Dec. 16 will have access to medications that can lessen the risk of severe disease through the country’s National Health Service (NHS). Two medications will be available:…

Blocking the protein SGLT1, which regulates glucose uptake in cells, may be a useful in treating cystic fibrosis (CF), according to research done in a cell model of the disease. SGLT1 inhibitors are likely less effective that currently approved modulators for patients with eligible mutations, its scientists noted, but…

Many women with cystic fibrosis (CF) wish to have biological children, but they often lack proper education and resources about fertility preservation, a U.S. study found. The study, “Fertility preservation in women with cystic fibrosis pre-lung transplantation: A mixed methods study,” was published in the Journal…

Children with cystic fibrosis (CF) have significantly higher level of fibrocytes — cells associated with diseases marked by fibrosis or scarring — in their bloodstream relative to healthy children, a study reported. Findings further revealed that these fibrocyte levels were lower during CF exacerbations than stable disease, and lower…

The Cystic Fibrosis Foundation is funding three new early-stage research awards worth more than $1.8 million to bolster the development of potential gene therapies for cystic fibrosis (CF). “This funding will support critical early steps necessary for the development of genetic therapies for cystic fibrosis,” William Skach, MD, executive…

The Cystic Fibrosis Foundation announced a $3.5 million investment in Pulmocide to support the company in developing an inhaled medication, opelconazole, to prevent fungal infections — specifically Aspergillus — in lung transplant patients. This funding will go toward a planned, multicenter Phase 2 clinical trial of opelconazole to…

In children with cystic fibrosis (CF), evidence of the bacteria Pseudomonas aeruginosa was associated with poorer lung function — based on predicted forced expiration volume in one second, FEV1% — while those testing positive for rhinovirus, which frequently causes the common cold, were more likely to have better…

Epithelial cells collected from the nasal passages and grown in the lab under a specialized protocol could be a useful model for studying the molecular underpinnings of cystic fibrosis (CF) and testing potential treatments, a study reported. The study, “Correlating genotype with phenotype using CFTR-mediated whole-cell…

A complete analysis of the CFTR gene, which is defective in cystic fibrosis (CF), identifies potential disease-causing mutations that would be missed by standard testing, as well as variations that may explain differences in disease course and treatment responses, a study of more than 5,000 CF patients shows. Still,…