Cystic Fibrosis News Today Forums Forums Science and Research CF Therapies Symdeko and Orkambi Seen to Also Ease Inflammation

  • paul-met-debbie

    February 10, 2022 at 4:53 am

    And Trikafta/Kaftrio seems to do this as well. At least in my experience, since taking Kaftrio inflammation is almost absent. How about you?

  • williamryan

    June 20, 2023 at 8:15 am

    I personally look forward to the day that I can experience one of these medicines. Thankfully my lungs have been okay, otherwise.

  • tim-blowfield

    July 7, 2023 at 8:18 pm

    ‘Tis logical that we see a reduction in inflammation in persons taking these modulators. More normal mucous  which can be more easily swept from the airways may be expected to reduce the bacterial in the lungs. Similarly, more normal mucous on other mucous membranes may be expected to reduce the bacterial load on those surfaces.

    But what are we seeing in other organs? Are we seeing improved Adrenal function?  Improvement in osteoporosis from both an improvement in digestion and in Parathyroid function? And muscle (incl cardiac) function? (improvement due to improvement in the intracellular electrolyte environment?)

    So much we need to learn! as these drugs may be expected to affect the function of every cell in the body. Let us look beyond just the lungs and see just what these drugs are doing.

    The old high calorie, high fat diet previously seen as suitable for those with CF may now be inappropriate for persons on modulators as digestion improves and weight increases.


    • williamryan

      July 12, 2023 at 9:10 am

      I think the high fat, high calorie diet is slowly being moved away from the CF Community. Now, yes, some people still have to abide by it (like myself), but my understanding is that it’s not the necessity it once was as patients find themselves going through digestion problems due to that diet. In regards to the other stuff you mentioned, I’m not sure we’ll understand the full negative and positive results of what the modulators have caused.

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