Co-infection with the bacterium Pseudomonas aeruginosa can increase the potency of therapies that kill Candida albicans, an infectious fungus, according to a new study. The study, “Pseudomonas Synergizes with Fluconazole against Candida during Treatment of Polymicrobial Infection,” was published in Infection and Immunity. Pseduomonas and Candida are both microorganisms…

People with cystic fibrosis (CF) are more frequently infected with oral Candida fungus and carry a higher number of fungi than healthy individuals, a study has found. All fungal species identified in the study’s CF patients were susceptible to currently available anti-fungal medications. The study, “Oral…

The presence of the fungus Aspergillus fumigatus is linked to lower respiratory-related quality of life in people with cystic fibrosis (CF), a study has found. The study,  “The presence of Aspergillus fumigatus is associated with worse respiratory quality of life in cystic fibrosis,” was published in…

Disease severity in cystic fibrosis (CF) may be associated with an overreaction of the immune system to the fungus Aspergillus fumigatus, particularly due to a type of white blood cell called a phagocyte — which ingests and kills invading organisms — a study suggests.  U.K.

Key results of a Phase 1/1b clinical trial of Pulmatrix’s lead treatment for fungal infections in asthma and cystic fibrosis (CF) are expected by mid-2018, the company reports. The trial, which started in February, is focusing on pulmazole’s safety and patients’ ability to tolerate it. Pulmatrix expects the results to…

Cystic Fibrosis Foundation Therapeutics has given Pulmatrix a grant to test the safety of PUR1900 as a treatment for allergic bronchopulmonary aspergillosis (ABPA) in cystic fibrosis and asthma patients. The grant will allow Pulmatrix to assess the safety of the anti-fungal drug this fall, paving the way for a Phase 1/1B trial in…

Cystic fibrosis (CF) patients with a fungal infection caused by Scedosporium apiospermum may have a clinical presentation resembling plastic bronchitis. A case report presents this unusual scenario, alerting clinicians to consider such fungus infection when encountering similar cases. Plastic bronchitis is characterized by a dysfunctional flow of lymph fluid, leading to the…

Read the Articles Here: Orkambi (lumacaftor/ivacaftor) For Cystic Fibrosis Pulmonary Function in CF Improves with High Frequency Chest Wall Oscillation Fungus with a Defense Against Bacteria Observed in Cystic Fibrosis Study    …

Pulmatrix, Inc. released animal-based research data at the 2015 North American Cystic Fibrosis Conference indicating that PUR1900 (iSPERSE™-formulated itraconazole) helped fight against Aspergillus fumigatus in rats. The fungus causes lung infection in cystic fibrosis. Concentrations of PUR1900 were high in the lungs but low in the overall body of the rats, indicating that…

In light of the news that almost 50% of cystic fibrosis patients are infected with Aspergillus mold, health leaders are reminding patients that it is important to limit exposure to agents that can cause infection for…