Posts by: Santiago Gisler

cystic fibrosis, News

Expression of a peptide called RpoN* in antibiotic-resistant Pseudomonas aeruginosa isolates from cystic fibrosis (CF) patients made the bacteria more susceptible to antibiotics and reduced virulence in a roundworm ... Read more

May 21, 2019May 21, 2019

Incidence of CF-related Diabetes Stable in Pediatric CF, Canadian Study Finds

cystic fibrosis, News

The incidence rate of cystic fibrosis-related diabetes (CFRD) in children with cystic fibrosis (CF) has remained stable over time, according to a Canadian multi-center registry study. According to the ... Read more

May 2, 2019May 2, 2019

FDA Approves Kalydeco for Treatment of 6- to 12-month-old Infants with Cystic Fibrosis

cystic fibrosis, News

The U.S. Food and Drug Administration (FDA) has approved Kalydeco (ivacaftor) for the treatment of infants from six to 12 months old, who have cystic fibrosis (CF) and at least ... Read more

April 30, 2019April 30, 2019

CF-associated Bacteria and Fungi Affect Each Other’s Growth, According to In Vitro Study

cystic fibrosis, News

Physical and signaling interactions between two pathogen groups that often affect patients with cystic fibrosis (CF) — Pseudomonas aeruginosa bacteria and Scedosporium fungi — result in a growth effect (inhibition or enhancement) of these microorganisms, ... Read more

April 26, 2019April 26, 2019

CFF Awards TB Alliance $5.1M to Develop Treatments for Multidrug-resistant NTM Infections

cystic fibrosis, News

The not-for-profit organization TB Alliance will receive up to $5.1 million from the Cystic Fibrosis Foundation (CFF) to advance the discovery and development of treatments for multidrug-resistant nontuberculous mycobacteria (NTM) ... Read more

April 23, 2019April 23, 2019

AmorChem, UdeS Team Up to Advance Research of Natural Antibiotic Against Infections Linked to CF

cystic fibrosis, News

The early-stage venture capital fund AmorChem has entered an agreement with Université de Sherbrooke (UdeS) and TransferTech Sherbrooke, in Canada, to optimize the antibiotic tomatidine for treating infections associated with cystic ... Read more

April 15, 2019June 27, 2019

Incidence of Liver Disease and Cirrhosis Climbing in CF Patients, UK Registry Study Says

cystic fibrosis, News

A higher incidence of liver disease was found in people with cystic fibrosis (CF) in the U.K., according to a large cohort registry study. As liver disease is the third ... Read more

April 9, 2019June 21, 2019

Large Sugar Molecule Disrupts B. cepacia Bacteria from CF Patients, Study Shows

News

An experimental large sugar molecule called poly (acetyl, arginyl) glucosamine, or PAAG, was able to disrupt treatment-resistant biofilms formed by Burkholderia cepacia complex bacteria extracted from patients with cystic fibrosis ... Read more

April 3, 2019April 3, 2019

Phase 2a Trial Will Test Molgradex in CF Patients with NTM Infections

cystic fibrosis, News

Savara Pharmaceuticals has launched a Phase 2a clinical study to evaluate the effectiveness of Molgradex in cystic fibrosis (CF) patients with chronic nontuberculous mycobacterial (NTM) lung infections. Molgradex is an ... Read more

March 28, 2019May 17, 2019

Costs for CF Therapies Could Double in 2019, According to Pharmacy Benefit Manager

cystic fibrosis, News

Costs for approved cystic fibrosis (CF) treatments and new approvals — including therapies extended to more age groups or targeting new mutations — could double in price, according to ... Read more