News

CFF Grants $1.6M to Study Lung Transplant Complications

The Cystic Fibrosis Foundation (CFF) has awarded $1.6 million to support research focused on identifying biomarkers of chronic lung allograft dysfunction (CLAD) — a complication of lung transplants — in people with cystic fibrosis (CF). A total of eight grants have been awarded, which will each focus on…

Home Monitoring in CF May Help Detect Pulmonary Exacerbations

Home monitoring with a mobile phone-linked spirometry device may provide an effective way of detecting pulmonary exacerbations — episodes of a sudden worsening of respiratory symptoms — in people with cystic fibrosis (CF), a pilot study suggests. The findings showed more pulmonary exacerbations were identified through home monitoring…

KIT2014 Increased CFTR Modulator Effects in Preclinical Study

KIT2014, an experimental treatment that Kither Biotech is developing to treat cystic fibrosis (CF) and other lung diseases, was able to reduce inflammation, relax the airways, and improve the functionality of CFTR modulators in preclinical models, a study shows. Kither is planning to launch a Phase 1/2a clinical…

IV Antibiotics May Be No Better Than Inhaled Ones for P. aeruginosa

In children with cystic fibrosis (CF) and a first or new-onset Pseudomonas aeruginosa infection, antibiotics given intravenously are not more effective at eliminating the bacteria than inhaled antibiotics given alone or as combination therapy, a Turkish study suggests.  Intravenous (IV) treatment was also associated with more pulmonary exacerbations and poorer lung function after…

CFF Awards $15.9M to Eloxx for Clinical Development of ELX-02

The Cystic Fibrosis Foundation (CFF) has awarded up to $15.9 million to Eloxx Pharmaceuticals to support the company’s clinical program for ELX-02, an investigational therapy for cystic fibrosis (CF) patients with nonsense mutations. A total of $7 million will be provided upfront, with additional funding granted based on…

Trikafta Costs to be Subsidized for Eligible Australians

Beginning April 1 the Australian government will subsidize the cost of Trikafta (elexacaftor/tezacaftor/ivacaftor) for patients with cystic fibrosis (CF) under the Australian Pharmaceutical Benefits Scheme (PBS), dramatically reducing out-of-pocket expenses for eligible Australians. The subsidy was made possible by a reimbursement agreement reached between Trikafta’s developer, Vertex…