Treatment with Orkambi (lumacaftor/ivacaftor) and/or Symdeko (tezacaftor/ivacaftor) may lessen liver damage in children and adolescents with cystic fibrosis (CF) who have liver involvement, new data indicate. “We detected improvements in validated noninvasive biomarkers of liver fibrosis [scarring] and cirrhosis in children and adolescents treated with” these therapies, the…
News
Treatment with Trikafta can help people with cystic fibrosis (CF) to put on weight, according to new data from a small clinical trial. These findings indicate that traditional guidelines for CF nutrition — which urge a…
Treatment with SP-101, an investigational gene therapy that Spirovant Sciences is developing for people with cystic fibrosis (CF) who are unable to benefit from current treatments, effectively increased CFTR gene activity in a ferret model of the disease, the company reported. Katherine Excoffon, PhD,…
Since the approval of Trikafta in the U.S., Nationwide Children’s Hospital in Ohio has seen a steep increase in the number of women with cystic fibrosis (CF) choosing to become pregnant. “Due to the large pregnancy volume we…
Aceragen reached an agreement to acquire Arrevus, including its late-stage clinical program of ARV-1801 — now called ACG-721 — an experimental oral therapy for pulmonary exacerbations in cystic fibrosis (CF) patients. Aceragen is planning to launch a Phase 2/3 clinical trial in the second half of 2022…
The Cystic Fibrosis (CF) Foundation has invested $3 million in Armata Pharmaceuticals to support development of AP-PA02, a bacteriophage now being evaluated in a clinical trial for its ability to treat respiratory infections caused by Pseudomonas aeruginosa in people with cystic fibrosis (CF). “We are pleased by…
A platform to help people with cystic fibrosis (CF) better adhere to inhalation treatment, called the CFHealthHub, led to a substantial increase in the number taking medications as directed, according to a yearlong study. Although no benefits in lung function or pulmonary exacerbations were detected relative to usual care,…
Health Canada has granted priority review to an application that seeks to expand the approval of Trikafta to cover children with cystic fibrosis (CF) as young as 6 years. “We are pleased that [the application] has been accepted for Priority Review by Health Canada and we look forward…
Young children with cystic fibrosis (CF), relative to age-matched peers with disorders also affecting the lungs, show differences in bacterial communities and inflammation of the lower airways starting at around age 2, a study reported. A lesser variety of bacterial classes and more inflammation in the lower airways —…
Funding totaling £750,000 ($1,028,550) for a Strategic Research Centre (SRC) in the United Kingdom is expected to speed development of antibiotics to battle the lung infections that most cystic fibrosis (CF) patients experience. The four-year award from the Cystic Fibrosis Trust and the Cystic Fibrosis Foundation…
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