Researchers have synthesized two new molecules that are able to kill Staphylococcus aureus and Pseudomonas aeruginosa — two species of bacteria that commonly cause lung infections in people with cystic fibrosis (CF). These new molecules, known as synthetic nano-engineered antimicrobial polymers or SNAPs, showed synergistic bacteria-killing effects when combined with…

BX004, a phage therapy candidate for Pseudomonas aeruginosa infections in people with cystic fibrosis (CF), was able to effectively kill a range of antibiotic-resistant bacterial strains under laboratory conditions, new data show. These findings were shared in the poster “Phage therapy for chronic Pseudomonas aeruginosa infections in Cystic Fibrosis…

An enzyme produced using computer design, in combination with the antibiotic tobramycin, efficiently kills Pseudomonas aeruginosa, a pathogen that often infects the lungs of patients with cystic fibrosis (CF), a study shows. It works to neutralize a metabolite called pyocyanin, required by P. aeruginosa to attach to surfaces…

Pel, a complex sugar molecule produced by Pseudomonas aeruginosa, contributes to the bacterium’s ability to aggregate and resist both antibiotics and mucus thinners in people with cystic fibrosis (CF) by binding to an abundant component of their thick mucus, a study reports. These findings shed light on the underlying mechanisms of the…

Pseudomonas aeruginosa mutate into a mucoid form in the lungs of people with cystic fibrosis (CF), creating biofilms that render these bacteria more resistant and more damaging, a study reported. Its researchers suggest a way of studying P. aeruginosa cells to identify treatments…

The common mutations that cause Pseudomonas aeruginosa to lose their ability to move are associated with a higher production of two complex sugar molecules implicated in the formation of biofilms — slimy layers of microorganisms that stick to wet surfaces and protect them from antibiotics and the host’s…

Microbion has been awarded up to $17.1 million from the nonprofit CARB-X and the Cystic Fibrosis Foundation to complete preclinical and Phase 1 clinical studies of its inhaled antimicrobial medication pravibismane for treating cystic fibrosis (CF) patients with lung infections. CARB-X — Combating Antibiotic-Resistant Bacteria…

Expression of a peptide called RpoN* in antibiotic-resistant Pseudomonas aeruginosa isolates from cystic fibrosis (CF) patients made the bacteria more susceptible to antibiotics and reduced virulence in a roundworm infection model, a study has found. The study, “Blocking RpoN reduces virulence of Pseudomonas aeruginosa isolated from cystic…

Removing a key metabolite called pyruvate from Pseudomonas aeruginosa and Staphylococcus aureus bacteria biofilms — two of the most common bacteria found in cystic fibrosis (CF) patients — could help boost the effectiveness of antibiotics, a study reports. The study, “Pyruvate-depleting conditions induce biofilm dispersion and enhance…

A therapy that involves a synthetic cationic antimicrobial peptide (CAP) can decrease Pseudomonas aeruginosa biofilm formation alone or in combination with another antimicrobial agent called tobramycin. Cystic fibrosis (CF) patients are susceptible to repeated bacterial infections. Infection with Pseudomonas aeruginosa (P. aeruginosa) is particularly harmful, since it has been shown to decrease…