Proper representation in clinical trials has long been a challenge for minorities with rare diseases like cystic fibrosis (CF), risking — and often leading to — inequities in care and fewer effective treatments for these patients. To this end, members of the CF community, including patients, researchers, physicians, and…
Kaftrio, marketed as Trikafta in the U.S., may be effective in people with cystic fibrosis (CF) who have one F508del mutation plus one other unknown mutation in the disease-causing gene, a study in cells taken from three such patients suggests. The results indicate that the combination therapy, which…
Source water levels of a metal called molybdenum is a significant environmental risk factor for nontuberculous mycobacteria (NTM) infection among people in Colorado with cystic fibrosis (CF), a database study focused on that state reported. NTM infection, caused by Mycobacterium abscessus (M. abscessus), is a difficult-to-treat bacterial infection, and…
Yap and Taz — two proteins involved in lung injury responses and regeneration — suppress the maturation of mucus-producing goblet cells and limit mucus levels in the lungs, according to a study of mice. These findings suggest that promoting Yap/Taz’s activity may be a potential therapeutic approach to limit the…
Nominations are now open for the worldwide 2022 Black Pearl Awards from Eurordis-Rare Diseases Europe. The 12 award categories recognize individual advocates, policy makers, researchers, organizations, and companies who work to make a difference for the global rare disease community. The deadline for nominations is Sept. 10…
Wrinkling on the palm of the hands after a short immersion in water may serve as a fast, easy and inexpensive test for an initial diagnosis of cystic fibrosis (CF), a study reports. Compared to healthy children in this study, those with CF developed signs of palm wrinkling — swelling,…
Inflammation in the airways of people with cystic fibrosis (CF) regulates the pH of the surface liquid and increases the response to approved CFTR modulators, a cell-based study suggested. Airway inflammation may be a key determinant in response to CF medicines, the researchers noted. “To advance personalized CFTR…
To examine the socioeconomic impact of cystic fibrosis (CF) on patients, caregivers, and society, Cystic Fibrosis Canada (CF Canada) is partnering for a questionnaire study with The Conference Board of Canada. CF patients and caregivers across Canada wanting in taking part in this research, called “The Social…
During adolescence and young adulthood, healthy siblings of cystic fibrosis (CF) patients have to find ways to achieve a balance between the illness of their brother or sister, family organization, and their own needs, a small study in Italy reported. Coping strategies included dampening emotional awareness, normalizing their life…
Eloxx Pharmaceuticals announced it expects to share data later this year from the first four treatment groups of a Phase 2 program evaluating the investigational therapy ELX-02 in people with cystic fibrosis (CF) who have at least one G542X mutation. “Given the substantial efforts of our clinical team,…
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